ERN1 and BAX

Number of citations of the paper that reports this interaction (PMID 16645094)
140

Data Source:
HPRD (in vitro, in vivo)

		ERN1	BAX
Gene Name		endoplasmic reticulum to nucleus signaling 1	BCL2-associated X protein
Image
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Vesicular Exosome Bcl-2 Family Protein Complex BAX Complex
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protein Binding Lipid Binding Channel Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Cleavage Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest RNA Splicing Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Protein Metabolic Process MRNA Splicing, Via Endonucleolytic Cleavage And Ligation HAC1-type Intron Splice Site Recognition And Cleavage Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Peptidyl-serine Trans-autophosphorylation	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Viral Process Hypothalamus Development Cerebral Cortex Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Oligomerization Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Protein Oligomerization Protein Homooligomerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Cellular Response To Organic Substance Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Retinal Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		IRE1alpha activates chaperones Unfolded Protein Response (UPR)	Activation, translocation and oligomerization of BAX Programmed Cell Death Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2 UBC	25 interactors: BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID BNIPL ERN1 KCNA3 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 SNCA UHRF2 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		2081	581
HPRD ID		04943	02498
Ensembl ID		ENSG00000178607	ENSG00000087088
Uniprot IDs		O75460	Q07812
PDB IDs		2HZ6 3P23	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Protein Processing Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Neuron Death Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Signal Transduction Regulation Of Proteolysis Protein Metabolic Process Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Neuron Death Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Homodimerization Activity Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Binding	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Release Of Cytochrome C From Mitochondria Mitochondrion Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Endopeptidase Activity Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Intersection) ?