ERN1 and P4HB

Number of citations of the paper that reports this interaction (PubMedID 32149426)
68

Data Source:
BioGRID (pull down)

		ERN1	P4HB
Description		endoplasmic reticulum to nucleus signaling 1	prolyl 4-hydroxylase subunit beta
Image
GO Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Protein-disulfide Reductase Activity Isomerase Activity Thiol Oxidase Activity Enzyme Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Endothelial Cell Proliferation MRNA Processing RNA Catabolic Process MRNA Catabolic Process Protein Phosphorylation Apoptotic Process Response To Unfolded Protein Negative Regulation Of Gene Expression Regulation Of Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response Positive Regulation Of JNK Cascade MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Insulin Processing Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Migration
Pathways		IRE1alpha activates chaperones IRE1alpha activates chaperones	Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling
Drugs		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib	Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)
Interacting Genes		15 interacting genes: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 RNF10 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2	54 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERN1 ERO1A ERO1B ESR1 FAM20C FEZ1 FNDC3B FZD10 GARIN6 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 OGT P4HA2 P4HA3 PDE4B PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69
Entrez ID		2081	5034
HPRD ID		04943	07181
Ensembl ID		ENSG00000178607	ENSG00000185624
Uniprot IDs		O75460	A0A024R8S5 P07237
PDB IDs		2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K 6XDB 6XDD 6XDF 7BMK 8UVL	1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S 7ZSC 8EOJ 8GDY
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Protein Catabolic Process Regulation Of Signal Transduction BAK Complex B Cell Negative Selection Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein-containing Complex Assembly Cellular Response To Topologically Incorrect Protein Regulation Of Cell Communication Regulation Of Signaling Protein Modification Process Positive Regulation Of Protein Metabolic Process Post-embryonic Camera-type Eye Morphogenesis IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Intracellular Signaling Cassette Protein Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Apoptotic Process Apoptotic Process Involved In Blood Vessel Morphogenesis Regulation Of JNK Cascade Cell Death Programmed Cell Death Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein Modification Process Post-embryonic Eye Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Chaperone-mediated Autophagy Tumor Necrosis Factor Binding	Protease Binding Identical Protein Binding Endoplasmic Reticulum Lumen Collagen Type I Trimer Intermediate Filament Cellular Response To Oxygen-containing Compound Protein Binding Extracellular Space Collagen Fibril Organization Cellular Response To Glucose Stimulus Response To Amino Acid Response To Monosaccharide Tissue Development Response To Kainic Acid Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Keratinization Cellular Response To Carbohydrate Stimulus Procollagen-proline 4-dioxygenase Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Response To Tumor Cell Extracellular Matrix Organization Extracellular Structure Organization Response To Oxidative Stress Thiol Oxidase Activity Response To Carbohydrate Intracellular Glucose Homeostasis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Proteolysis Odontoblast Differentiation Biomineral Tissue Development Keratin Filament Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Leukocyte Mediated Cytotoxicity Cellular Response To Growth Factor Stimulus Negative Regulation Of Innate Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Response To Xenobiotic Stimulus Fibrillar Collagen Trimer Positive Regulation Of Axon Regeneration Regulation Of Endothelial Cell Migration Regulation Of Lymphocyte Mediated Immunity Carbohydrate Homeostasis Response To Estradiol Glucose Homeostasis Negative Regulation Of Translational Initiation Negative Regulation Of Leukocyte Activation Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Growth Factor Positive Regulation Of Proteolysis
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