MAP3K1 and NOTCH1

Number of citations of the paper that reports this interaction (PubMedID 27806347)
51

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		MAP3K1	NOTCH1
Description		mitogen-activated protein kinase kinase kinase 1	notch receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Tight Junction	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Adherens Junction Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Late Endosome Membrane Receptor Complex Cell Periphery Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Transcription Regulator Activator Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Luteolysis In Utero Embryonic Development Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inhibition Of Neuroepithelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Coronary Sinus Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cardioblast Proliferation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Negative Regulation Of Extracellular Matrix Constituent Secretion Pericardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Immune Response Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axonogenesis Axon Guidance Foregut Morphogenesis Endoderm Development Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Notch Signaling Pathway Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Glial Cell Differentiation Gene Expression Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Calcium-ion Regulated Exocytosis Cell Differentiation In Spinal Cord Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Protein Catabolic Process Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Embryonic Limb Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Animal Organ Regeneration Response To Muramyl Dipeptide Response To Lipopolysaccharide Negative Regulation Of Collagen Biosynthetic Process Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Population Proliferation Tissue Regeneration Retinal Cone Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Endothelial Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Neuron Fate Commitment Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Venous Blood Vessel Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Assembly Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production Cardiac Muscle Cell Myoblast Differentiation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Neuroendocrine Cell Differentiation Regulation Of Cell Adhesion Involved In Heart Morphogenesis Heart Trabecula Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Hypoxia Distal Tubule Development Collecting Duct Development Regulation Of Stem Cell Proliferation Glomerular Mesangial Cell Development Epithelial Cell Fate Commitment T-helper 17 Type Immune Response Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Interleukin-17-mediated Signaling Pathway Chemical Synaptic Transmission, Postsynaptic Negative Regulation Of Cold-induced Thermogenesis Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Positive Regulation Of Aorta Morphogenesis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm NFE2L2 regulating tumorigenic genes Regulation of NFE2L2 gene expression Somitogenesis
Drugs		AZD-8330 Binimetinib Fostamatinib
Diseases			Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 19330030 20453838 29059683 23535729 17529967 31757997) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32902719 28334899) Triglycerides ( 20686565 24097068) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Inflammatory bowel disease ( 28067908) Length of menstrual cycle ( 26732621) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 28957414) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)
Interacting Genes		94 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 ZFAND3 ZFAND5	88 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DDR1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBP1 FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 HOXA1 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC00261 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MBD1 MDM2 MEF2C MFNG NFKB1 NLK NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SHANK3 SMAD3 SNAI1 SNW1 STC1 TLE3 USP10 USP12 USP2 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID		4214	4851
HPRD ID		19599	01827
Ensembl ID		ENSG00000095015	ENSG00000148400
Uniprot IDs		Q13233	P46531
PDB IDs		6WHB	1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8 8OR5 8ORY 8ORZ 9B3G 9B3N
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytosol Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Catabolic Process Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Modification Process Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Modification Process Cytoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Regulation Of Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Signal Transduction VCP-NPL4-UFD1 AAA ATPase Complex Protein K48-linked Ubiquitination Nucleoplasm ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Intracellular Protein Transport Protein Transport Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Identical Protein Binding Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Non-canonical NF-kappaB Signal Transduction DNA Repair Regulation Of Immune Response Regulation Of Post-translational Protein Modification	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Notch Binding Lymphocyte Activation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Signaling Leukocyte Activation Cell Activation Somitogenesis Regulation Of Cell Development Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Segmentation Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Protein Modification Process Mononuclear Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Lymphocyte Differentiation Tube Morphogenesis Regulation Of Gene Expression Positive Regulation Of Developmental Process Leukocyte Differentiation Regulation Of RNA Metabolic Process Regionalization Morphogenesis Of An Epithelium Pattern Specification Process Positive Regulation Of Gene Expression Regulation Of Multicellular Organismal Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?