MAP3K1 and ARHGAP4

Number of citations of the paper that reports this interaction (PMID 14581471)
14

Data Source:
BioGRID (two hybrid)

		MAP3K1	ARHGAP4
Gene Name		mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	Rho GTPase activating protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Microtubule Focal Adhesion Growth Cone
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding JUN Kinase Kinase Activity Protein Kinase Binding	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding
	Biological Process	Activation Of MAPKK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Epithelial Cell Morphogenesis Protein Phosphorylation Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of JUN Kinase Activity Apoptotic Mitochondrial Changes Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Wound Healing Innate Immune Response Eyelid Development In Camera-type Eye Cellular Response To Mechanical Stimulus	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Fibroblast Migration Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Breast cancer ( 17529967 23535729 20453838 19330030) Triglycerides ( 20686565) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		30 interactors: ACTN1 ARHGAP4 BRCA1 CHUK CRTC1 DCAF7 DTX1 GRB2 GSK3B IKBKB JUN MAP2K4 MAP2K7 MAPK1 MAPK3 MAPK8 MAPK9 NFKBIA NR4A1 PAK1 RAF1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L6 UBE2W YWHAE	2 interactors: MAP3K1 NRAS
Entrez ID		4214	393
HPRD ID		19599	02063
Ensembl ID		ENSG00000095015	ENSG00000089820
Uniprot IDs		Q13233	F5GZW3 P98171
PDB IDs			2EPD
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Fc Receptor Signaling Pathway Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response Regulation Of Immune System Process Response To Abiotic Stimulus Response To Organic Substance Defense Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Response To Stress Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Stress Immune System Process Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Activation Of MAPKK Activity Fc-epsilon Receptor Signaling Pathway MAPK Cascade Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Actin Cytoskeleton Organization Regulation Of MAPK Cascade Actin Filament-based Process Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Immune Response Eyelid Development In Camera-type Eye Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Skeletal Muscle Tissue Development Cell Morphogenesis Regulation Of Protein Phosphorylation Epithelium Development Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Synaptic Transmission, GABAergic Immune Response Regulation Of Immune System Process Regulation Of Rac Protein Signal Transduction Regulation Of Phosphorylation Defense Response Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis
Tagcloud ?		5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants	abcf2 adprtl1 amy2b atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Difference) ?		5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants	abcf2 adprtl1 amy2b atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4
Tagcloud (Intersection) ?