USP19 and HIF1A

Number of citations of the paper that reports this interaction (PMID 22128162)
4

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		USP19	HIF1A
Gene Name		ubiquitin specific peptidase 19	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Motile Cilium RNA Polymerase II Transcription Factor Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding
	Biological Process	Protein Deubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress Negative Regulation Of Skeletal Muscle Tissue Development Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia	Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Transcription, DNA-templated Cellular Iron Ion Homeostasis Signal Transduction Notch Signaling Pathway Lactation Visual Learning Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Receptor Biosynthetic Process Response To Muscle Activity Axon Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 UBC	67 interactors: APEX1 AR ARNT ARNT2 ARNTL ATM CDC34 CDKN2A CITED2 COPS5 CREBBP CSNK2A1 CTNNB1 DAP3 EGLN1 EGLN2 EGLN3 EP300 FHL2 GNB2L1 HDAC1 HDAC2 HDAC5 HIF1AN HIF3A HSP90AA1 HSP90AB1 JUN MAFG MAFK MAPK1 MAPK3 MAX MCM7 MDM2 MTA1 NAA10 NAA11 NCOA1 NCOA2 NDN NR4A1 OS9 PER1 PGK1 PKM PLD1 PSMA7 RB1 RUNX2 RWDD3 SAT1 SEPT9 SP1 SSX4 STAT3 STUB1 SUMO1 SUMO2 TP53 TRAF6 TSGA10 UBE2D1 USP19 USP20 VHL VHLL
Entrez ID		10869	3091
HPRD ID		18278	04517
Ensembl ID		ENSG00000172046	ENSG00000100644
Uniprot IDs		O94966	A8MYV6 D0VY79 Q16665
PDB IDs		1WH0	1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Cycle Epithelial To Mesenchymal Transition Protein Ubiquitination Cell Morphogenesis Protein Modification By Small Protein Conjugation MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Positive Regulation Of Signal Transduction Mesenchymal Cell Development Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Mesenchymal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Anatomical Structure Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Mesenchyme Development Regulation Of Intracellular Signal Transduction Regulation Of Nitric-oxide Synthase Activity Cell Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Stem Cell Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Mitotic Cell Cycle Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of TOR Signaling Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Stem Cell Differentiation Neural Fold Elevation Formation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Oxidoreductase Activity Cell Projection Morphogenesis Toll-like Receptor 4 Signaling Pathway Regulation Of Catalytic Activity Cell Differentiation Regulation Of Cell Death Cell Part Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process	Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Response To Hypoxia Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Response To Growth Factor
Tagcloud ?		adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement exerts fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr	actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1
Tagcloud (Difference) ?		adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement exerts fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr	actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1
Tagcloud (Intersection) ?