USP19 and LAMTOR4

Number of citations of the paper that reports this interaction (PubMedID 23500468)
0

Data Source:
BioGRID (two hybrid)

		USP19	LAMTOR4
Description		ubiquitin specific peptidase 19	late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Lysosome Lysosomal Membrane Late Endosome Membrane Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Hsp90 Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway	Regulation Of Cell Size Positive Regulation Of TOR Signaling TORC1 Signaling Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling
Pathways		Ub-specific processing proteases	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 TP53 UBC	1 interacting genes: USP19
Entrez ID		10869	389541
HPRD ID		18278	17380
Ensembl ID		ENSG00000172046	ENSG00000188186
Uniprot IDs		A0A0A0MR08 A0A8I5KT08 A0A8I5KV50 A0A8I5KXK1 O94966	A0A087WT92 A0A087WV46 Q0VGL1
PDB IDs		1WH0 4X3G 6K7W 6KHV 6KQV	5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Cell Death Regulation Of Apoptotic Process Apoptotic Process Protein-containing Complex Regulation Of Post-translational Protein Modification Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Neural Precursor Cell Proliferation Regulation Of Thymocyte Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Lactate Metabolic Process Neuron Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Histone Deacetylase Binding Regulation Of Protein Stability Disordered Domain Specific Binding Regulation Of Apoptotic Signaling Pathway Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Necrotic Cell Death Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Import Into Nucleus GTPase Binding Supramolecular Fiber Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Response To Antibiotic Regulation Of Neuroblast Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Metabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Protein Metabolic Process Neuroblast Proliferation Transcription Coactivator Binding CTP Binding	Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway Regulation Of Skeletal Muscle Tissue Development Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development Hsp90 Protein Binding Regulation Of Response To Endoplasmic Reticulum Stress Cysteine-type Deubiquitinase Activity Protein Deubiquitination ERAD Pathway Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity
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