USP19 and SIAH2

Number of citations of the paper that reports this interaction (PMID 23500468)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		USP19	SIAH2
Gene Name		ubiquitin specific peptidase 19	siah E3 ubiquitin protein ligase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding
	Biological Process	Protein Deubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress Negative Regulation Of Skeletal Muscle Tissue Development Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS			Breast cancer ( 22951594)
Protein-Protein Interactions		13 interactors: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 UBC	39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1
Entrez ID		10869	6478
HPRD ID		18278	03737
Ensembl ID		ENSG00000172046	ENSG00000181788
Uniprot IDs		O94966	O43255
PDB IDs		1WH0
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Cycle Epithelial To Mesenchymal Transition Protein Ubiquitination Cell Morphogenesis Protein Modification By Small Protein Conjugation MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Positive Regulation Of Signal Transduction Mesenchymal Cell Development Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Signal Transduction Mesenchymal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Anatomical Structure Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Mesenchyme Development Regulation Of Intracellular Signal Transduction Regulation Of Nitric-oxide Synthase Activity Cell Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Stem Cell Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Mitotic Cell Cycle Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of TOR Signaling Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Stem Cell Differentiation Neural Fold Elevation Formation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Oxidoreductase Activity Cell Projection Morphogenesis Toll-like Receptor 4 Signaling Pathway Regulation Of Catalytic Activity Cell Differentiation Regulation Of Cell Death Cell Part Morphogenesis Regulation Of Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process	Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway
Tagcloud ?		adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement exerts fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr	adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Difference) ?		adenoviral catalytic chop collectively concomitant creating defect deubiquitinating display enhancement exerts fusion implicate isoform isoforms l6 localized modulated modulates muscle myoblast myofibrillar myogenin possibility raised regeneration thapsigargin unfolded upr	adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Intersection) ?