USP19 and CKAP5

Number of citations of the paper that reports this interaction (PubMedID 23500468)
0

Data Source:
BioGRID (two hybrid)

		USP19	CKAP5
Description		ubiquitin specific peptidase 19	cytoskeleton associated protein 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Mitotic Spindle
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Hsp90 Protein Binding	Protein Binding Microtubule Binding Tubulin Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein-containing Complex Organization Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation
Pathways		Ub-specific processing proteases	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)
Interacting Genes		14 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 TP53 UBC	16 interacting genes: ARHGEF16 AURKA CACNA1A CEBPA CLASP1 CLK1 DYRK1A HSPA13 NDC80 OLIG2 PTPRN2 SLAIN2 SUMO2 TOP1 TTC3 USP19
Entrez ID		10869	9793
HPRD ID		18278	10830
Ensembl ID		ENSG00000172046	ENSG00000175216
Uniprot IDs		A0A0A0MR08 A0A8I5KT08 A0A8I5KV50 A0A8I5KXK1 O94966	Q14008
PDB IDs		1WH0 4X3G 6K7W 6KHV 6KQV	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?		Cell Death Regulation Of Apoptotic Process Apoptotic Process Protein-containing Complex Regulation Of Post-translational Protein Modification Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Neural Precursor Cell Proliferation Regulation Of Thymocyte Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Lactate Metabolic Process Neuron Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Histone Deacetylase Binding Regulation Of Protein Stability Disordered Domain Specific Binding Regulation Of Apoptotic Signaling Pathway Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Necrotic Cell Death Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Import Into Nucleus GTPase Binding Supramolecular Fiber Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Response To Antibiotic Regulation Of Neuroblast Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Metabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Protein Metabolic Process Neuroblast Proliferation Transcription Coactivator Binding CTP Binding	Protein Serine/threonine/tyrosine Kinase Activity Spindle Assembly Involved In Female Meiosis I Animal Organ Regeneration Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process HMG Box Domain Binding Regulation Of Microtubule-based Process Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regeneration Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Plus-end Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Microtubule Nucleation Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Cell Cycle Phase Transition Kinetochore Positive Regulation Of Microtubule Polymerization Regulation Of Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Peptidyl-serine Phosphorylation Spindle Microtubule Microtubule Cytoskeleton Organization Cell Division Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Histone H3T45 Kinase Activity Kinetochore Adaptor Activity Centrosomal Corona Regulation Of Cytoskeleton Organization Establishment Of Spindle Localization
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