USP19

Description		ubiquitin specific peptidase 19
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Hsp90 Protein Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		14 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 TP53 UBC
Entrez ID		10869
HPRD ID		18278
Ensembl ID		ENSG00000172046
Uniprot IDs		A0A0A0MR08 A0A8I5KT08 A0A8I5KV50 A0A8I5KXK1 O94966
PDB IDs		1WH0 4X3G 6K7W 6KHV 6KQV
Enriched GO Terms of Interacting Partners?		Cell Death Regulation Of Apoptotic Process Apoptotic Process Protein-containing Complex Regulation Of Post-translational Protein Modification Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Neural Precursor Cell Proliferation Regulation Of Thymocyte Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Lactate Metabolic Process Neuron Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Histone Deacetylase Binding Regulation Of Protein Stability Disordered Domain Specific Binding Regulation Of Apoptotic Signaling Pathway Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Necrotic Cell Death Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Import Into Nucleus GTPase Binding Supramolecular Fiber Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Response To Antibiotic Regulation Of Neuroblast Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Metabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Protein Metabolic Process Neuroblast Proliferation Transcription Coactivator Binding CTP Binding
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