USP19 and BIRC3

Number of citations of the paper that reports this interaction (PubMedID 21849505)
42

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		USP19	BIRC3
Description		ubiquitin specific peptidase 19	baculoviral IAP repeat containing 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Hsp90 Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway	Apoptotic Process Cell Surface Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Spermatogenesis Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Pathways		Ub-specific processing proteases	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		14 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 TP53 UBC	37 interacting genes: BIRC5 CASP3 CASP7 CASP9 CD40 CTBP2 CYFIP2 DIABLO DZIP3 GLMN GSPT1 HAX1 HTRA2 IKBKE MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1
Entrez ID		10869	330
HPRD ID		18278	03426
Ensembl ID		ENSG00000172046	ENSG00000023445
Uniprot IDs		A0A0A0MR08 A0A8I5KT08 A0A8I5KV50 A0A8I5KXK1 O94966	Q13489
PDB IDs		1WH0 4X3G 6K7W 6KHV 6KQV	2UVL 3EB5 3EB6 3M0A 3M0D 7NK0
Enriched GO Terms of Interacting Partners?		Cell Death Regulation Of Apoptotic Process Apoptotic Process Protein-containing Complex Regulation Of Post-translational Protein Modification Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Neural Precursor Cell Proliferation Regulation Of Thymocyte Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Lactate Metabolic Process Neuron Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Histone Deacetylase Binding Regulation Of Protein Stability Disordered Domain Specific Binding Regulation Of Apoptotic Signaling Pathway Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Necrotic Cell Death Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Import Into Nucleus GTPase Binding Supramolecular Fiber Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Response To Antibiotic Regulation Of Neuroblast Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Metabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Protein Metabolic Process Neuroblast Proliferation Transcription Coactivator Binding CTP Binding	Post-translational Protein Modification Protein Modification Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity CD40 Receptor Complex Protein Polyubiquitination Proteolysis Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Catabolic Process Transferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Regulation Of Primary Metabolic Process Positive Regulation Of Signaling Positive Regulation Of Post-translational Protein Modification Apoptotic Signaling Pathway Protein Catabolic Process DNA Damage Response Regulation Of Metabolic Process Regulation Of Programmed Cell Death Fibroblast Apoptotic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Response To Stress Intrinsic Apoptotic Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Neuron Apoptotic Process Regulation Of Signal Transduction
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