FRS2 and PAK1

Number of citations of the paper that reports this interaction (PMID 12154000)
4

Data Source:
HPRD (in vitro)

		FRS2	PAK1
Gene Name		fibroblast growth factor receptor substrate 2	p21 protein (Cdc42/Rac)-activated kinase 1
Image
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Membrane	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Gastrulation With Mouth Forming Second Organ Induction Ventricular Septum Development Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neuroblast Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Fc-epsilon Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Optic Placode Formation Involved In Camera-type Eye Formation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951) Response to diuretic therapy ( 18591461)
Protein-Protein Interactions		22 interactors: CBL CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 SOS1 SRC	83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83
Entrez ID		10818	5058
HPRD ID		06372	03995
Ensembl ID		ENSG00000166225	ENSG00000149269
Uniprot IDs		L7RTG7 Q8WU20	B3KNX7 Q13153
PDB IDs		1XR0	1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Locomotion Cellular Response To Insulin Stimulus Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Response To Insulin Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Peptide Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Motility Cellular Response To Organic Substance Response To Peptide Hormone Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Peptide Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Neuron Development Regulation Of Phosphorylation Response To Organic Substance Activation Of Protein Kinase Activity Cellular Response To Hormone Stimulus Fc Receptor Signaling Pathway Signaling Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Autophosphorylation Positive Regulation Of Kinase Activity Generation Of Neurons	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response
Tagcloud ?		adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Difference) ?		adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Intersection) ?