FRS2 and NTRK3

Number of citations of the paper that reports this interaction (PMID 10092678)
41

Data Source:
BioGRID (pull down)

		FRS2	NTRK3
Gene Name		fibroblast growth factor receptor substrate 2	neurotrophic tyrosine kinase, receptor, type 3
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Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Membrane	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Gastrulation With Mouth Forming Second Organ Induction Ventricular Septum Development Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neuroblast Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Fc-epsilon Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Optic Placode Formation Involved In Camera-type Eye Formation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951) Response to diuretic therapy ( 18591461)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		22 interactors: CBL CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 SOS1 SRC	20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1
Entrez ID		10818	4916
HPRD ID		06372	01870
Ensembl ID		ENSG00000166225	ENSG00000140538
Uniprot IDs		L7RTG7 Q8WU20	B7Z7U4 H0YND1 Q16288 Q96CY4
PDB IDs		1XR0	1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Locomotion Cellular Response To Insulin Stimulus Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Response To Insulin Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Peptide Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Motility Cellular Response To Organic Substance Response To Peptide Hormone Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Peptide Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Neuron Development Regulation Of Phosphorylation Response To Organic Substance Activation Of Protein Kinase Activity Cellular Response To Hormone Stimulus Fc Receptor Signaling Pathway Signaling Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Autophosphorylation Positive Regulation Of Kinase Activity Generation Of Neurons	Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity
Tagcloud ?		adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		adapter adenoviruses bdnf branching cascades cortical docking facilitates fgf frs3 gab1 gab2 goals grb2 impairs multiprotein neurite neurotrophic neurotrophin neurotrophins outgrowth phosphatidylinositide pi3 route shp2 stimulates trk twofold utilize	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
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