FRS2 and DDR1

Number of citations of the paper that reports this interaction (PubMedID 10783152)
0

Data Source:
HPRD (in vitro, in vivo)

		FRS2	DDR1
Description		fibroblast growth factor receptor substrate 2	discoidin domain receptor tyrosine kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Endomembrane System Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Fibroblast Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phosphatase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Gastrulation With Mouth Forming Second Organ Induction Lens Development In Camera-type Eye Ventricular Septum Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuroblast Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Lens Placode Formation Involved In Camera-type Eye Formation Regulation Of Epithelial Cell Proliferation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Lens Fiber Cell Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cardiac Muscle Cell Differentiation	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Female Pregnancy Embryo Implantation Lactation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Neuron Projection Development Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways		PI3K Cascade PIP3 activates AKT signaling Frs2-mediated activation Frs2-mediated activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants	Non-integrin membrane-ECM interactions
Drugs			Imatinib Fostamatinib Pralsetinib
Diseases
GWAS		Complete remission in asthma ( 29786918) Heel bone mineral density ( 30598549) Height ( 18391951 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 25673412) Logical memory (delayed recall) in normal cognition ( 29274321) Microalbuminuria ( 31511532) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Thyroid stimulating hormone levels ( 32769997) Urinary albumin-to-creatinine ratio ( 31511532)	Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: BECN1 CBL CDK3 CRK DDR1 FGFR1 GAB1 GRB2 INSR KDR MAPK1 MAPK3 NCK1 NTRK1 NTRK2 NTRK3 PAK1 PIN1 PRKCI PRKCZ PTPN11 PTPRF RET RND1 RPS6 SOS1 SRC YJU2	20 interacting genes: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NOTCH1 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		10818	780
HPRD ID		06372	02678
Ensembl ID		ENSG00000166225	ENSG00000204580
Uniprot IDs		L7RTG7 Q8WU20	A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs		1XR0 2MFQ	3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 5SAU 5SAV 5SAW 5SAX 5SAY 5SAZ 5SB0 5SB1 5SB2 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6 7FEH 8PE9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Tyrosine Kinase Activity Cell Migration Ephrin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Cell Motility Protein Autophosphorylation ERBB Signaling Pathway Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Phosphotyrosine Residue Binding Positive Regulation Of Cell Projection Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Regulation Of Cell Projection Organization Cell Development Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration ATP Binding Receptor Complex Ephrin Receptor Binding Positive Regulation Of Cell Motility Neurotrophin Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Locomotion	Fibrillar Collagen Trimer Collagen Type XI Trimer Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To Growth Factor Stimulus Collagen Fibril Organization Receptor Tyrosine Kinase Binding Response To Growth Factor Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Type II Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Structural Constituent Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Cell Surface Receptor Signaling Pathway Anatomical Structure Homeostasis Tissue Homeostasis Platelet-derived Growth Factor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Muscle Cell Differentiation Muscle Tissue Morphogenesis Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of MAPK Cascade Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Developmental Process Cartilage Condensation Cartilage Development Positive Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Cell-cell Adhesion Cell Aggregation Signal Transduction Negative Regulation Of Multicellular Organismal Process Prostate Gland Epithelium Morphogenesis Insulin Receptor Binding Positive Regulation Of Signal Transduction
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