CTSC and CAPN1

Number of citations of the paper that reports this interaction (PMID 12358155)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CTSC	CAPN1
Gene Name		cathepsin C	calpain 1, (mu/I) large subunit
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endoplasmic Reticulum Golgi Apparatus Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein Self-association Chaperone Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Aging Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways		MHC class II antigen presentation Adaptive Immune System	Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CAPN1 CTSL XRN2	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		1075	823
HPRD ID		03841	00253
Ensembl ID		ENSG00000109861	ENSG00000014216
Uniprot IDs		P53634	B2RDI5 B4DWH5 P07384
PDB IDs		1K3B 2DJF 2DJG 3PDF	1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Macrophage Apoptotic Process Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Cellular Response To Thyroid Hormone Stimulus Receptor Catabolic Process Response To Thyroid Hormone RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process DNA Catabolic Process, Exonucleolytic	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?