CTSC and CTSL

Number of citations of the paper that reports this interaction (PubMedID 11327826)
0

Data Source:
HPRD (in vitro)

		CTSC	CTSL
Description		cathepsin C	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein-folding Chaperone Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Negative Regulation Of Myelination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases		Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		5 interacting genes: CAPN1 CTSL PPDPF USP2-AS1 XRN2	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		1075	1514
HPRD ID		03841	00293
Ensembl ID		ENSG00000109861	ENSG00000135047
Uniprot IDs		P53634	P07711 Q5T8F0 Q9HBQ7
PDB IDs		1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Calpain Complex Mammary Gland Involution Cysteine-type Peptidase Activity Elastin Metabolic Process Endolysosome Lumen Macrophage Apoptotic Process Elastin Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Chromaffin Granule Fusion Of Virus Membrane With Host Endosome Membrane Enkephalin Processing Transcription Termination Site Sequence-specific DNA Binding 5'-3' RNA Exonuclease Activity NMDA Selective Glutamate Receptor Signaling Pathway Inflammatory Cell Apoptotic Process Macromolecule Catabolic Process Termination Of RNA Polymerase II Transcription Self Proteolysis 5'-3' Exonuclease Activity Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Receptor-mediated Endocytosis Of Virus By Host Cell Proteoglycan Binding Endocytosis Involved In Viral Entry Into Host Cell Myeloid Cell Apoptotic Process Receptor Catabolic Process Endocytic Vesicle Lumen DNA-templated Transcription Termination Peptidase Activity Response To Thyroid Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Hydrolase Activity Lysosome CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Ionotropic Glutamate Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding T Cell Lineage Commitment Glycoprotein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Aggresome 3'-5'-RNA Exonuclease Activity Catabolic Process Ligand-gated Ion Channel Signaling Pathway Collagen Catabolic Process Zymogen Activation	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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