CTSC and CTSL

Number of citations of the paper that reports this interaction (PMID 11327826)
22

Data Source:
HPRD (in vitro)

		CTSC	CTSL
Gene Name		cathepsin C	cathepsin L
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endoplasmic Reticulum Golgi Apparatus Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein Self-association Chaperone Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Aging Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		MHC class II antigen presentation Adaptive Immune System	Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CAPN1 CTSL XRN2	27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		1075	1514
HPRD ID		03841	00293
Ensembl ID		ENSG00000109861	ENSG00000135047
Uniprot IDs		P53634	P07711 Q9HBQ7
PDB IDs		1K3B 2DJF 2DJG 3PDF	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Macrophage Apoptotic Process Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Myeloid Cell Apoptotic Process Inflammatory Cell Apoptotic Process Cellular Response To Thyroid Hormone Stimulus Receptor Catabolic Process Response To Thyroid Hormone RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process DNA Catabolic Process, Exonucleolytic	Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation
Tagcloud ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Difference) ?		abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic	a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored
Tagcloud (Intersection) ?