CTSC and XRN2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		CTSC	XRN2
Description		cathepsin C	5'-3' exoribonuclease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein-folding Chaperone Binding	3'-5'-RNA Exonuclease Activity Transcription Termination Site Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Zinc Ion Binding 5'-3' Exonuclease Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Negative Regulation Of Myelination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Termination RRNA Processing Termination Of RNA Polymerase II Transcription RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases		Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)	Autism spectrum disorder ( 30804558) Hip circumference adjusted for BMI ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: CAPN1 CTSL PPDPF USP2-AS1 XRN2	39 interacting genes: ALDH1B1 APP ATRN CEBPA COMT CRY2 CSNK2A1 CTSC DSCAM DSCR9 DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 OGT PLEKHF2 PRAME PSMA3 RNF10 RNF8 TARDBP TIPARP TOLLIP TTC23 TTC3 UPF2 USP16 USP7 YTHDF1
Entrez ID		1075	22803
HPRD ID		03841	10309
Ensembl ID		ENSG00000109861	ENSG00000088930
Uniprot IDs		P53634	B4DZC3 Q9H0D6
PDB IDs		1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?		Calpain Complex Mammary Gland Involution Cysteine-type Peptidase Activity Elastin Metabolic Process Endolysosome Lumen Macrophage Apoptotic Process Elastin Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Chromaffin Granule Fusion Of Virus Membrane With Host Endosome Membrane Enkephalin Processing Transcription Termination Site Sequence-specific DNA Binding 5'-3' RNA Exonuclease Activity NMDA Selective Glutamate Receptor Signaling Pathway Inflammatory Cell Apoptotic Process Macromolecule Catabolic Process Termination Of RNA Polymerase II Transcription Self Proteolysis 5'-3' Exonuclease Activity Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Receptor-mediated Endocytosis Of Virus By Host Cell Proteoglycan Binding Endocytosis Involved In Viral Entry Into Host Cell Myeloid Cell Apoptotic Process Receptor Catabolic Process Endocytic Vesicle Lumen DNA-templated Transcription Termination Peptidase Activity Response To Thyroid Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Hydrolase Activity Lysosome CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Ionotropic Glutamate Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding T Cell Lineage Commitment Glycoprotein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Aggresome 3'-5'-RNA Exonuclease Activity Catabolic Process Ligand-gated Ion Channel Signaling Pathway Collagen Catabolic Process Zymogen Activation	Macromolecule Metabolic Process Protein Metabolic Process Macromolecule Catabolic Process Nuclear MRNA Surveillance Catabolic Process Positive Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Memory Symbiont-mediated Disruption Of Host Cell PML Body MRNA Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Catabolic Process Translation Positive Regulation Of Translational Elongation Regulation Of Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Response To Blue Light Regulation Of Translation Nuclear RNA Surveillance Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process RNA Surveillance Kinase Binding RNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytosol Regulation Of Translational Elongation TRNA Decay Regulation Of Glycolytic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteolysis Double-strand Break Repair Via Nonhomologous End Joining Nucleic Acid Metabolic Process Nucleoplasm Rhythmic Process
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