AKAP3 and GNA13

Number of citations of the paper that reports this interaction (PMID 11696326)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		AKAP3	GNA13
Gene Name		A kinase (PRKA) anchor protein 3	guanine nucleotide binding protein (G protein), alpha 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Sperm Fibrous Sheath Sperm Principal Piece	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Kinase A Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Movement Of Cell Or Subcellular Component Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Single Fertilization Acrosome Reaction Protein Localization Regulation Of Protein Kinase A Signaling	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity
Pathways			Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AKAP4 GNA13 PRKAR2A ROPN1 ROPN1B ROPN1L SPA17	31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		10566	10672
HPRD ID		05256	05100
Ensembl ID		ENSG00000111254	ENSG00000120063
Uniprot IDs		O75969	B7Z7R0 F5H1G8 Q14344
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Motility Single Fertilization Movement Of Cell Or Subcellular Component Fertilization Epithelial Cilium Movement Sexual Reproduction Reproduction Cilium Movement Single Organism Reproductive Process Rho Protein Signal Transduction Reproductive Process Positive Regulation Of Phospholipase Activity Spermatogenesis Male Gamete Generation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Gamete Generation Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cell Motility Ras Protein Signal Transduction Negative Regulation Of CAMP-dependent Protein Kinase Activity Microtubule-based Movement Locomotion Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Phospholipase D Activity Activation Of Protein Kinase A Activity Regulation Of Protein Kinase A Signaling Fusion Of Sperm To Egg Plasma Membrane Sperm Capacitation Blood Coagulation Hemostasis Plasma Membrane Fusion Acrosome Reaction Renal Water Homeostasis Intracellular Signal Transduction Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Cellular Response To Glucagon Stimulus Water Transport Binding Of Sperm To Zona Pellucida	Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction
Tagcloud ?		acev2 acu akap4v2 configurations degenerate frames gapdhs hundreds hypothetical noncanonical odf1 orthologous paralogues permutations prm1 prm2 prm3 resemble retrogene retroposons smcp spata18 spermatids tnp1 tnp2 uac utrs yrs yrss	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Difference) ?		acev2 acu akap4v2 configurations degenerate frames gapdhs hundreds hypothetical noncanonical odf1 orthologous paralogues permutations prm1 prm2 prm3 resemble retrogene retroposons smcp spata18 spermatids tnp1 tnp2 uac utrs yrs yrss	18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Intersection) ?