CAMKK2 and CEP63

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		CAMKK2	CEP63
Description		calcium/calmodulin dependent protein kinase kinase 2	centrosomal protein 63
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion	DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)	Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		8 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 CRYAA NEDD4 PRKACA	66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774
Entrez ID		10645	80254
HPRD ID		06467	07826
Ensembl ID		ENSG00000110931	ENSG00000182923
Uniprot IDs		Q96RR4	A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y3O 6Y4K 6Y6B 6Y8A 8TUC	6CSU 6CSV 7W91
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium-mediated Signaling Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Monoatomic Ion Transport Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Export From Nucleus Calcium/calmodulin-dependent Protein Kinase Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cellular Localization Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Transport Regulation Of Blood Circulation Regulation Of Glycolytic Process Regulation Of Biological Quality Regulation Of Protein Metabolic Process Protein-containing Complex Establishment Of Localization In Cell Sperm Midpiece Regulation Of Synapse Organization Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Transport Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Response To Metal Ion Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cation Transmembrane Transport Protein Serine Kinase Activity Protein Phosphorylation Formation Of Structure Involved In A Symbiotic Process Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Protein Catabolic Process	Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm
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