CAMKK2

Description		calcium/calmodulin dependent protein kinase kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs
Drugs		Fostamatinib
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)
Interacting Genes		8 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 CRYAA NEDD4 PRKACA
Entrez ID		10645
HPRD ID		06467
Ensembl ID		ENSG00000110931
Uniprot IDs		Q96RR4
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y3O 6Y4K 6Y6B 6Y8A 8TUC
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium-mediated Signaling Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Monoatomic Ion Transport Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Export From Nucleus Calcium/calmodulin-dependent Protein Kinase Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cellular Localization Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Transport Regulation Of Blood Circulation Regulation Of Glycolytic Process Regulation Of Biological Quality Regulation Of Protein Metabolic Process Protein-containing Complex Establishment Of Localization In Cell Sperm Midpiece Regulation Of Synapse Organization Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Transport Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Response To Metal Ion Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cation Transmembrane Transport Protein Serine Kinase Activity Protein Phosphorylation Formation Of Structure Involved In A Symbiotic Process Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Protein Catabolic Process
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