CAMKK2 and CAMK1

Number of citations of the paper that reports this interaction (PMID 9822657)
48

Data Source:
HPRD (in vitro)

		CAMKK2	CAMK1
Gene Name		calcium/calmodulin-dependent protein kinase kinase 2, beta	calcium/calmodulin-dependent protein kinase I
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cell Projection	Nucleus Cytoplasm
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Protein Localization Regulation Of Protein Binding Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA	15 interactors: APP ATF1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 GAPDH GCM1 HDAC5 MARK2 NOS1 SYN1
Entrez ID		10645	8536
HPRD ID		06467	05412
Ensembl ID		ENSG00000110931	ENSG00000134072
Uniprot IDs		Q96RR4	B0YIY3 Q14012
PDB IDs		2ZV2	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase C Activity Positive Regulation Of Intracellular Transport Cell Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transport Positive Regulation Of Phospholipase Activity Response To Light Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Synapse Structure Or Activity Cellular Response To Light Stimulus Regulation Of Cellular Localization Response To Radiation Cellular Response To Radiation Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process Regulation Of Transmembrane Transporter Activity Regulation Of Protein Binding Immune Response Positive Regulation Of Intracellular Protein Transport Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Catalytic Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Signal Transduction Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Rhodopsin Mediated Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Adenylate Cyclase Activity Innate Immune Response Regulation Of Binding Regulation Of Intracellular Protein Transport Signaling	Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Translation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Response To Metal Ion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-cysteine S-nitrosylation Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Metabolic Process Response To Organic Substance Phosphorylation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Organic Substance Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Response To Inorganic Substance Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Organic Cyclic Compound Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Regulation Of Cell Cycle Arrest Signal Transduction Regulation Of Catalytic Activity Cellular Protein Modification Process Cellular Response To Stimulus Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Protein Metabolic Process Response To Stress Notch Signaling Pathway Protein Phosphorylation
Tagcloud ?		akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Difference) ?		akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown
Tagcloud (Intersection) ?