CAMKK2 and CAMK4

Number of citations of the paper that reports this interaction (PMID 9822657)
48

Data Source:
HPRD (in vitro)

		CAMKK2	CAMK4
Gene Name		calcium/calmodulin-dependent protein kinase kinase 2, beta	calcium/calmodulin-dependent protein kinase IV
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cell Projection	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation	Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Nucleocytoplasmic Transport Inflammatory Response Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Neuron-neuron Synaptic Transmission Long-term Memory Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Myeloid Dendritic Cell Differentiation Innate Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Organelle biogenesis and maintenance Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Post NMDA receptor activation events Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF CaMK IV-mediated phosphorylation of CREB DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Mitochondrial biogenesis Signaling by ERBB2 CaMK IV-mediated phosphorylation of CREB Signaling by EGFR Activation of CaMK IV CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 17903302)
Protein-Protein Interactions		7 interactors: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA	10 interactors: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		10645	814
HPRD ID		06467	07169
Ensembl ID		ENSG00000110931
Uniprot IDs		Q96RR4	Q16566
PDB IDs		2ZV2	2W4O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Export From Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase C Activity Positive Regulation Of Intracellular Transport Cell Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transport Positive Regulation Of Phospholipase Activity Response To Light Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Synapse Structure Or Activity Cellular Response To Light Stimulus Regulation Of Cellular Localization Response To Radiation Cellular Response To Radiation Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process Regulation Of Transmembrane Transporter Activity Regulation Of Protein Binding Immune Response Positive Regulation Of Intracellular Protein Transport Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Catalytic Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Signal Transduction Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Rhodopsin Mediated Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of Adenylate Cyclase Activity Innate Immune Response Regulation Of Binding Regulation Of Intracellular Protein Transport Signaling	Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Peptidyl-cysteine S-nitrosylation Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Metabolic Process Response To Muramyl Dipeptide Signaling Peptidyl-amino Acid Modification Cell Communication Second-messenger-mediated Signaling Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Immune System Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Glial Cell Differentiation Response To Stress Defense Response Endocardial Cushion Development Response To Cytokine Negative Regulation Of Muscle Cell Differentiation Signal Transduction Negative Regulation Of Osteoblast Differentiation Response To Organic Substance Positive Regulation Of Gliogenesis Response To Hypoxia Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Myotube Differentiation Regulation Of Cell Development
Tagcloud ?		akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
Tagcloud (Difference) ?		akt apoptosis br calcium calmodulin er estrogen exact irrespective knockdown largely mb mcf mda moderately neural oncotarget pcp4 pep19 phospho potentially regulates serve sk slightly still thr308 unknown	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
Tagcloud (Intersection) ?