CAMKK2 and CAMK4

Number of citations of the paper that reports this interaction (PubMedID 9822657)
0

Data Source:
HPRD (in vitro)

		CAMKK2	CAMK4
Description		calcium/calmodulin dependent protein kinase kinase 2	calcium/calmodulin dependent protein kinase IV
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Projection Neuron Projection	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion	Adaptive Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs		Fostamatinib	K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 30929738 31959851 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Type 1 diabetes ( 34012112)
Interacting Genes		8 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 CRYAA NEDD4 PRKACA	10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		10645	814
HPRD ID		06467	07169
Ensembl ID		ENSG00000110931	ENSG00000152495
Uniprot IDs		Q96RR4	Q16566
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y3O 6Y4K 6Y6B 6Y8A 8TUC	2W4O
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcium-mediated Signaling Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Monoatomic Ion Transport Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Export From Nucleus Calcium/calmodulin-dependent Protein Kinase Activity Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cellular Localization Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Transport Regulation Of Blood Circulation Regulation Of Glycolytic Process Regulation Of Biological Quality Regulation Of Protein Metabolic Process Protein-containing Complex Establishment Of Localization In Cell Sperm Midpiece Regulation Of Synapse Organization Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Transport Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Response To Metal Ion Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cation Transmembrane Transport Protein Serine Kinase Activity Protein Phosphorylation Formation Of Structure Involved In A Symbiotic Process Protein Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Protein Catabolic Process	Peptidyl-cysteine S-nitrosylase Activity Chromatin DNA Binding Nucleus Nucleoplasm Cytosol Endocardial Cushion Development Negative Regulation Of Myotube Differentiation Response To Muramyl Dipeptide Calcium/calmodulin-dependent Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Response To UV Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of Gene Expression NADP Binding Calmodulin Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Myotube Differentiation Rhythmic Process Transcription Coactivator Binding Negative Regulation Of Metabolic Process Immune System Process Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Catabolic Process Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Cellular Response To Growth Factor Stimulus Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation
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