ATG7 and MAP1LC3A

Number of citations of the paper that reports this interaction (PubMedID 31857589)
59

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ATG7	MAP1LC3A
Description		autophagy related 7	microtubule associated protein 1 light chain 3 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Autophagosome Assembly Mitophagy Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Positive Regulation Of Catabolic Process Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Response To Nutrient Levels Protein Modification By Small Protein Conjugation Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Regulation Of Macromolecule Metabolic Process Cellular Response To Hyperoxia Regulation Of Primary Metabolic Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation
Pathways		Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 30578418 27618452 27618447) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		11 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B TRIM7	100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304
Entrez ID		10533	84557
HPRD ID		12293	03144
Ensembl ID		ENSG00000197548	ENSG00000101460
Uniprot IDs		B3KQM6 O95352	Q9H492
PDB IDs			3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Mitophagy Autophagosome Protein-containing Complex Disassembly Organelle Assembly Atg12 Transferase Activity Phospholipid Binding Atg8-family Ligase Activity Cellular Response To Starvation Atg12-Atg5-Atg16 Complex Response To Stress Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Cellular Component Assembly Glycophagy Ubiquitin Protein Ligase Binding Catabolic Process GABA Receptor Binding Response To Lead Ion Ubiquitin-like Protein Transferase Activity Cytosol Glycogen Catabolic Process Cellular Response To Copper Ion Nucleophagy Protein-containing Complex Organization Cytoplasmic Vesicle Polysaccharide Catabolic Process Cellular Response To Stress Response To Nutrient Levels Response To Copper Ion Organelle Organization Beta-tubulin Binding Organelle Membrane Endomembrane System Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Atg8-family Conjugating Enzyme Activity	Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity
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