ATG7 and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		ATG7	EEF1D
Description		autophagy related 7	eukaryotic translation elongation factor 1 delta
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Autophagosome Assembly Mitophagy Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Positive Regulation Of Catabolic Process Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Response To Nutrient Levels Protein Modification By Small Protein Conjugation Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Regulation Of Macromolecule Metabolic Process Cellular Response To Hyperoxia Regulation Of Primary Metabolic Process	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation
Pathways		Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation	Eukaryotic Translation Elongation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 30578418 27618452 27618447) Waist-to-hip ratio adjusted for BMI ( 34021172)	Schizophrenia ( 31268507)
Interacting Genes		11 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B TRIM7	45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1
Entrez ID		10533	1936
HPRD ID		12293	00560
Ensembl ID		ENSG00000197548	ENSG00000104529
Uniprot IDs		B3KQM6 O95352	B2RAR6 P29692
PDB IDs			2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Mitophagy Autophagosome Protein-containing Complex Disassembly Organelle Assembly Atg12 Transferase Activity Phospholipid Binding Atg8-family Ligase Activity Cellular Response To Starvation Atg12-Atg5-Atg16 Complex Response To Stress Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Cellular Component Assembly Glycophagy Ubiquitin Protein Ligase Binding Catabolic Process GABA Receptor Binding Response To Lead Ion Ubiquitin-like Protein Transferase Activity Cytosol Glycogen Catabolic Process Cellular Response To Copper Ion Nucleophagy Protein-containing Complex Organization Cytoplasmic Vesicle Polysaccharide Catabolic Process Cellular Response To Stress Response To Nutrient Levels Response To Copper Ion Organelle Organization Beta-tubulin Binding Organelle Membrane Endomembrane System Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Atg8-family Conjugating Enzyme Activity	Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding
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