ATG7 and EEF1D

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		ATG7	EEF1D
Gene Name		autophagy related 7	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasm Cytosol Axoneme	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	DNA Binding Translation Elongation Factor Activity Signal Transducer Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	Mitochondrion Degradation Liver Development Cellular Protein Modification Process Protein Lipidation C-terminal Protein Lipidation Cellular Amino Acid Metabolic Process Cellular Response To Nitrogen Starvation Mitochondrion Organization Adult Walking Behavior Cellular Response To Starvation Post-embryonic Development Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Macroautophagy Protein Ubiquitination Cerebellar Purkinje Cell Layer Development Pyramidal Neuron Development Central Nervous System Neuron Axonogenesis Cerebral Cortex Development Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of Nucleus Negative Stranded Viral RNA Replication Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Late Nucleophagy Positive Regulation Of Protein Catabolic Process Neurological System Process Cardiac Muscle Cell Development Membrane Fusion Positive Regulation Of Mucus Secretion Cellular Response To Hyperoxia Negative Regulation Of Histone H4-K16 Acetylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Signal Transduction Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B	33 interactors: ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS ERP27 FOS FRA10AC1 GARS HEXDC KARS KTN1 MAP1B NR2F1 POT1 PRKCA RELA RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 VARS
Entrez ID		10533	1936
HPRD ID		12293	00560
Ensembl ID		ENSG00000197548	ENSG00000104529
Uniprot IDs		O95352	B2RAR6 D3DWK1 P29692
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Autophagy Vacuole Organization Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Membrane Fusion Response To Stress Cellular Response To Stress Cell Communication Catabolic Process Response To External Stimulus Cellular Component Assembly Cellular Response To Stimulus Membrane Organization Response To Stimulus Cellular Metabolic Process Autophagy In Response To ER Overload Organelle Organization Synaptic Growth At Neuromuscular Junction Protein Lipidation Lipoprotein Biosynthetic Process Collateral Sprouting In Absence Of Injury Protein Transport Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Protein Localization Lipoprotein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Transport Axon Choice Point Recognition Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Neuron Remodeling ER Overload Response Metabolic Process Protein Localization Apoptotic Process Establishment Of Localization In Cell Programmed Cell Death	Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Axonogenesis Regulation Of Telomere Maintenance Via Telomerase Axon Development Negative Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Toll-like Receptor 10 Signaling Pathway Cell Differentiation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Telomere Maintenance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Viral Genome Replication Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Schwann Cell Differentiation Neuron Projection Development Neurotrophin TRK Receptor Signaling Pathway Cell Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Axon Guidance Chemotaxis Neurotrophin Signaling Pathway Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Histone H4 Acetylation
Tagcloud ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild
Tagcloud (Difference) ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild
Tagcloud (Intersection) ?