ATG7 and ATG10

Number of citations of the paper that reports this interaction (PubMedID 12482611)
0

Data Source:
HPRD (two hybrid)

		ATG7	ATG10
Description		autophagy related 7	autophagy related 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	Protein Binding Transferase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Atg12 Conjugating Enzyme Activity
	Biological Process	Autophagosome Assembly Mitophagy Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Positive Regulation Of Catabolic Process Protein Transport Macroautophagy Positive Regulation Of Protein Modification Process Response To Nutrient Levels Protein Modification By Small Protein Conjugation Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Regulation Of Macromolecule Metabolic Process Cellular Response To Hyperoxia Regulation Of Primary Metabolic Process	Autophagosome Assembly Mitophagy Autophagy ER Overload Response Protein Transport Protein Modification By Small Protein Conjugation
Pathways		Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF1 fusions Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy Macroautophagy
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 30578418 27618452 27618447) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adventurousness ( 30643258) Airway imaging phenotypes ( 26030696) Breast cancer ( 25751625 29059683) Carotid intima media thickness (mean) ( 31801372) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		11 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B TRIM7	4 interacting genes: ATG12 ATG5 ATG7 IRGM
Entrez ID		10533	83734
HPRD ID		12293	16497
Ensembl ID		ENSG00000197548	ENSG00000152348
Uniprot IDs		B3KQM6 O95352	Q9H0Y0
PDB IDs
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Mitophagy Autophagosome Protein-containing Complex Disassembly Organelle Assembly Atg12 Transferase Activity Phospholipid Binding Atg8-family Ligase Activity Cellular Response To Starvation Atg12-Atg5-Atg16 Complex Response To Stress Response To Starvation Microtubule Binding Cellular Response To Nutrient Levels Cellular Component Assembly Glycophagy Ubiquitin Protein Ligase Binding Catabolic Process GABA Receptor Binding Response To Lead Ion Ubiquitin-like Protein Transferase Activity Cytosol Glycogen Catabolic Process Cellular Response To Copper Ion Nucleophagy Protein-containing Complex Organization Cytoplasmic Vesicle Polysaccharide Catabolic Process Cellular Response To Stress Response To Nutrient Levels Response To Copper Ion Organelle Organization Beta-tubulin Binding Organelle Membrane Endomembrane System Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Atg8-family Conjugating Enzyme Activity	Autophagosome Organization Autophagosome Assembly Regulation Of Autophagosome Maturation Negative Regulation Of Defense Response To Virus Piecemeal Microautophagy Of The Nucleus Microautophagy Nucleophagy Vacuole Organization Positive Regulation Of Viral Translation Negative Regulation Of Type I Interferon Production Atg8-family Ligase Activity Autophagy Regulation Of Defense Response To Virus Autophagy Of Mitochondrion Atg12-Atg5-Atg16 Complex Phagocytic Vesicle Membrane Negative Regulation Of Innate Immune Response Cellular Response To Nitrogen Starvation Regulation Of Protein-containing Complex Disassembly Regulation Of Type I Interferon Production Transferase Complex Macroautophagy Regulation Of Macroautophagy Organelle Assembly Phagophore Assembly Site Membrane Negative Regulation Of Immune Response Protein Lipidation Negative Regulation Of Defense Response Cellular Component Assembly Negative Regulation Of Cytokine Production Autophagosome Maturation Autophagosome Membrane Regulation Of Autophagy Mitophagy Response To Virus Positive Regulation Of Viral Process Regulation Of Innate Immune Response Autophagosome Negative Regulation Of Immune System Process Atg8 Activating Enzyme Activity Atg12 Activating Enzyme Activity Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Axoneme Otolith Development C-terminal Protein Lipidation Regulation Of Viral Process Protein-containing Complex Disassembly Catabolic Process
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