ATG7 and ATG3

Number of citations of the paper that reports this interaction (PMID 11825910)
49

Data Source:
HPRD (in vivo)

		ATG7	ATG3
Gene Name		autophagy related 7	autophagy related 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasm Cytosol Axoneme	Cytoplasmic Ubiquitin Ligase Complex Cytosol
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	Protein Binding Atg8 Ligase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding
	Biological Process	Mitochondrion Degradation Liver Development Cellular Protein Modification Process Protein Lipidation C-terminal Protein Lipidation Cellular Amino Acid Metabolic Process Cellular Response To Nitrogen Starvation Mitochondrion Organization Adult Walking Behavior Cellular Response To Starvation Post-embryonic Development Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Macroautophagy Protein Ubiquitination Cerebellar Purkinje Cell Layer Development Pyramidal Neuron Development Central Nervous System Neuron Axonogenesis Cerebral Cortex Development Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of Nucleus Negative Stranded Viral RNA Replication Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Late Nucleophagy Positive Regulation Of Protein Catabolic Process Neurological System Process Cardiac Muscle Cell Development Membrane Fusion Positive Regulation Of Mucus Secretion Cellular Response To Hyperoxia Negative Regulation Of Histone H4-K16 Acetylation	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Protein Modification Process Protein Targeting To Membrane Protein Ubiquitination Mitochondrial Fragmentation Involved In Apoptotic Process Nucleophagy Regulation Of Cilium Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B	8 interactors: ATG12 ATG5 ATG7 BECN1 GABARAP GABARAPL2 MAP1LC3A MAP1LC3B
Entrez ID		10533	64422
HPRD ID		12293	10654
Ensembl ID		ENSG00000197548	ENSG00000144848
Uniprot IDs		O95352	Q9NT62
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Autophagy Vacuole Organization Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Membrane Fusion Response To Stress Cellular Response To Stress Cell Communication Catabolic Process Response To External Stimulus Cellular Component Assembly Cellular Response To Stimulus Membrane Organization Response To Stimulus Cellular Metabolic Process Autophagy In Response To ER Overload Organelle Organization Synaptic Growth At Neuromuscular Junction Protein Lipidation Lipoprotein Biosynthetic Process Collateral Sprouting In Absence Of Injury Protein Transport Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Protein Localization Lipoprotein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Transport Axon Choice Point Recognition Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Neuron Remodeling ER Overload Response Metabolic Process Protein Localization Apoptotic Process Establishment Of Localization In Cell Programmed Cell Death	Nucleophagy Cellular Response To Nitrogen Starvation Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Cellular Response To Starvation Autophagy Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Cellular Response To Extracellular Stimulus Vacuole Organization Response To Nutrient Levels Response To Extracellular Stimulus Mitochondrion Organization Organelle Assembly Membrane Fusion Cellular Response To Stress Catabolic Process Response To External Stimulus C-terminal Protein Lipidation Negative Regulation Of Histone H4-K16 Acetylation Organelle Organization Cellular Component Assembly Response To Stress Negative Regulation Of Histone H4 Acetylation Negative Stranded Viral RNA Replication Membrane Organization Protein Lipidation Regulation Of Histone H4 Acetylation Positive Regulation Of Mucus Secretion Lipoprotein Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Mucus Secretion Negative Regulation Of Histone Acetylation Cell Communication Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Viral Genome Replication Lipoprotein Metabolic Process Post-translational Protein Modification Cellular Response To Stimulus Positive Regulation Of Autophagy Regulation Of Histone Acetylation Negative Regulation Of Type I Interferon Production Cardiac Muscle Cell Development Response To Stimulus Cellular Response To Aluminum Ion Negative Regulation Of Chromosome Organization Regulation Of Type I Interferon Production
Tagcloud ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	alkaloids anticancer araguspongine araguspongines atg16l atg7 autophagic autophagy bt cascade docking dysregulations inositol kinases lc3a lyte macrocyclic marine met overexpressing oxaquinolizidine remarkably silico sponge trisphosphate tyrosine vacuole xestospongia xestospongin
Tagcloud (Difference) ?		a1 annexin autophagosome baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	alkaloids anticancer araguspongine araguspongines atg16l autophagic bt cascade docking dysregulations inositol kinases lc3a lyte macrocyclic marine met overexpressing oxaquinolizidine remarkably silico sponge trisphosphate tyrosine vacuole xestospongia xestospongin
Tagcloud (Intersection) ?		atg7 autophagy