AIM2 and ANP32B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AIM2	ANP32B
Description		absent in melanoma 2	acidic nuclear phosphoprotein 32 family member B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Site Of Double-strand Break Canonical Inflammasome Complex AIM2 Inflammasome Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Cysteine-type Endopeptidase Activator Activity	Protein Binding Histone Binding RNA Polymerase Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Immune Response DNA Damage Response Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta T Cell Homeostasis Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Maturation Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Cellular Homeostasis Pyroptotic Inflammatory Response Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Pyroptosome Complex Assembly	Vasculature Development Nucleosome Assembly Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development
Pathways		Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)	Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		4 interacting genes: ANP32B APPBP2 RNF4 SQSTM1	42 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2
Entrez ID		9447	10541
HPRD ID		05202	09803
Ensembl ID		ENSG00000163568	ENSG00000136938
Uniprot IDs		O14862	Q92688
PDB IDs		3RN2 3RN5 3VD8 4O7Q 6MB2 7K3R	2ELL 2RR6 8R1J 8R1L
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PML Body Post-translational Protein Modification Brown Fat Cell Proliferation Amphisome Regulation Of Protein Localization Regulation Of Kinetochore Assembly Macromolecule Catabolic Process Regulation Of Centromere Complex Assembly SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Proteolysis Lewy Body Response To Mitochondrial Depolarisation Protein Polyubiquitination Intracellular Membraneless Organelle Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Chromatin Ubiquitin-modified Protein Reader Activity Nucleoplasm Autolysosome Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Aggrephagy Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Regulation Of Ferroptosis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Complex Stability Positive Regulation Of Protein Localization Molecular Sequestering Activity Pexophagy Proteasomal Protein Catabolic Process Inclusion Body Cul2-RING Ubiquitin Ligase Complex RNA Polymerase Binding Positive Regulation Of Protein Export From Nucleus Ventricular System Development Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Long-term Synaptic Potentiation Intracellular Protein Transport	Nucleoplasm Nucleus Chromatin Remodeling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Protein Heterodimerization Activity Regulation Of Macromolecule Metabolic Process Developmental Growth DNA Binding Chromatin Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Primary Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death Regulation Of Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication DNA Damage Response Regulation Of Signaling Microglia Development Satellite Cell Activation Involved In Skeletal Muscle Regeneration Nucleosome Organization Chromatin Binding Chromosome Organization Protein Localization To Organelle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of Proteolysis Negative Regulation Of Metabolic Process Cytosol Apoptotic Process Regulation Of Gene Expression Kinetochore Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Mismatch Repair Complex Positive Regulation Of RNA Metabolic Process Protein Dephosphorylation
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