AIM2

Description		absent in melanoma 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Site Of Double-strand Break Canonical Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Immune Response DNA Damage Response Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta T Cell Homeostasis Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Maturation Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Cellular Homeostasis Pyroptotic Inflammatory Response Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Pyroptosome Complex Assembly
Pathways		Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		4 interacting genes: ANP32B APPBP2 RNF4 SQSTM1
Entrez ID		9447
HPRD ID		05202
Ensembl ID		ENSG00000163568
Uniprot IDs		O14862
PDB IDs		3RN2 3RN5 3VD8 4O7Q 6MB2 7K3R
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PML Body Post-translational Protein Modification Brown Fat Cell Proliferation Amphisome Regulation Of Protein Localization Regulation Of Kinetochore Assembly Macromolecule Catabolic Process Regulation Of Centromere Complex Assembly SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Proteolysis Lewy Body Response To Mitochondrial Depolarisation Protein Polyubiquitination Intracellular Membraneless Organelle Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Chromatin Ubiquitin-modified Protein Reader Activity Nucleoplasm Autolysosome Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Aggrephagy Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Regulation Of Ferroptosis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Complex Stability Positive Regulation Of Protein Localization Molecular Sequestering Activity Pexophagy Proteasomal Protein Catabolic Process Inclusion Body Cul2-RING Ubiquitin Ligase Complex RNA Polymerase Binding Positive Regulation Of Protein Export From Nucleus Ventricular System Development Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Long-term Synaptic Potentiation Intracellular Protein Transport
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