CTC1 and TPP1

Number of citations of the paper that reports this interaction (PMID 25172512)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CTC1	TPP1
Gene Name		CTS telomere maintenance complex component 1	tripeptidyl peptidase I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Stn1-Ten1 Complex	Mitochondrion Lysosome Melanosome Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Peptide Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Cellular Response To DNA Damage Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Hematopoietic Stem Cell Proliferation Replicative Senescence	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Peptide Catabolic Process Cellular Protein Metabolic Process Bone Resorption Neuromuscular Process Controlling Balance
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Telomere length ( 23001564)
Protein-Protein Interactions		2 interactors: APPBP2 TPP1	6 interactors: CTC1 NMB OBFC1 POT1 TERT TINF2
Entrez ID		80169	1200
HPRD ID		07980	06415
Ensembl ID			ENSG00000166340
Uniprot IDs		Q2NKJ3	O14773
PDB IDs			1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Regulation Of Establishment Of Blood-brain Barrier Intermembrane Transport Vitamin E Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Telomere Assembly Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Peptide Catabolic Process Regulation Of Telomerase Activity Intracellular Protein Transport Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Intracellular PH Reduction PH Reduction Protein Localization To Chromosome Bone Resorption Response To PH Positive Regulation Of DNA Binding Cellular Protein Localization Protein Transport Regulation Of Intracellular PH Vitamin Transport Regulation Of DNA Biosynthetic Process Establishment Of Protein Localization Regulation Of Cellular PH Negative Regulation Of DNA Replication Intracellular Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Positive Regulation Of Nuclease Activity Bone Remodeling Positive Regulation Of DNA Replication Regulation Of PH Telomere Maintenance Neuromuscular Process Controlling Balance Protein Localization Regulation Of DNA Binding Establishment Of Localization In Cell Negative Regulation Of Chromosome Organization Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA Metabolic Process Cellular Response To Unfolded Protein Vacuole Organization ER-nucleus Signaling Pathway	Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Assembly Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Homeostatic Process Telomere Formation Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization DNA Metabolic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Replicative Senescence Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Metabolic Process Negative Regulation Of RNA Interference Regulation Of Protein ADP-ribosylation Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Bone Marrow Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Protein Glycosylation
Tagcloud ?		blepharitis bmf congenita dermatologist dkc1 dyskeratosis ectropion entropion epiphora exudative eyelashes hoyeraal hreidarsson lacy leukodepleted multicolor nails nhp2 nop10 otolaryngologist pigmentation reticular revesz taurodauntism terc tinf2 triad trichiasis wrap53	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?		blepharitis bmf congenita dermatologist dkc1 dyskeratosis ectropion entropion epiphora exudative eyelashes hoyeraal hreidarsson lacy leukodepleted multicolor nails nhp2 nop10 otolaryngologist pigmentation reticular revesz taurodauntism terc tinf2 triad trichiasis wrap53	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?