TNP2 and PRKACB

Number of citations of the paper that reports this interaction (PMID 9837753)
2

Data Source:
BioGRID (enzymatic study)

		TNP2	PRKACB
Gene Name		transition protein 2 (during histone to protamine replacement)	protein kinase, cAMP-dependent, catalytic, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus	Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	DNA Binding Metal Ion Binding	Magnesium Ion Binding CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Multicellular Organismal Development Spermatogenesis Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Cell Differentiation Sperm Motility	Neural Tube Closure Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Negative Regulation Of Meiotic Cell Cycle Transmembrane Transport Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Multiple sclerosis ( 22190364) Type 1 diabetes ( 18978792)	Breast cancer (male) ( 23001122)
Protein-Protein Interactions		11 interactors: KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MDFI NOTCH2NL PRKACA PRKACB PRKACG PRKCA	12 interactors: ACVR1B APPBP2 ARFGAP1 CSNK2A1 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2
Entrez ID		7142	5567
HPRD ID		01831	01482
Ensembl ID		ENSG00000178279	ENSG00000142875
Uniprot IDs		Q05952 Q4VB56	B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Activation Of Protein Kinase A Activity Triglyceride Catabolic Process Energy Reserve Metabolic Process Acylglycerol Catabolic Process Renal Water Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Protein Transport Cellular Response To Glucagon Stimulus Neurotrophin TRK Receptor Signaling Pathway Water Transport Regulation Of Peptide Hormone Secretion Regulation Of Establishment Of Protein Localization Neurotrophin Signaling Pathway Histone H3-T6 Phosphorylation Fluid Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Water Homeostasis Regulation Of Hormone Secretion Response To Glucagon Gluconeogenesis Regulation Of Kinase Activity Activation Of Protein Kinase Activity Regulation Of Protein Localization Water Homeostasis Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Phosphorylation Hexose Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Regulation Of Protein Secretion Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Triglyceride Metabolic Process Renal System Process Positive Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy	Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Intracellular Protein Transport Protein Complex Disassembly Establishment Of Localization In Cell Locomotion Reproductive Process Cellular Protein Localization Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Sperm Motility Protein Transport Negative Regulation Of Axonogenesis Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Multicellular Organismal Reproductive Process Fertilization, Exchange Of Chromosomal Proteins Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Intracellular Transport Cellular Localization Multicellular Organism Reproduction Regulation Of Cell Growth Regulation Of Cell Cycle Viral Transcription Regulation Of Mitotic Cell Cycle Hair Follicle Development Male Pronucleus Assembly Positive Regulation Of Trophoblast Cell Migration Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hair Cycle Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Cell Cycle Hair Cycle Reproduction Cell Death Death Regulation Of Protein Phosphorylation Negative Regulation Of Hair Follicle Development Protein Localization Negative Regulation Of Neuron Projection Development Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Single Fertilization
Tagcloud ?		669t adapt adaptations boars breed breeds coincide colocalizes colour concordant domesticated domestication ednrb gpr149 implied indigenous jmjd1c litter massively melanocyte mitf pigs prm1 prm2 selections spotted sweep synonymous tongcheng	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		669t adapt adaptations boars breed breeds coincide colocalizes colour concordant domesticated domestication gpr149 implied indigenous jmjd1c litter massively melanocyte mitf pigs prm1 prm2 selections spotted sweep synonymous tongcheng	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?		ednrb