SEC23B and SYNE4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SEC23B	SYNE4
Description		SEC23 homolog B, COPII component	spectrin repeat containing nuclear envelope family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Refractive error ( 32231278)
Interacting Genes		26 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 RIN1 SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UBA52 UBC UGT1A1	56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648
Entrez ID		10483	163183
HPRD ID		11543	08776
Ensembl ID		ENSG00000101310	ENSG00000181392
Uniprot IDs		A0A2R8YFH5 Q15437	Q8N205
PDB IDs			6R16 6WMD
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Vesicle Cargo Loading Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Vesicle Transport COPII-coated ER To Golgi Transport Vesicle ER To Golgi Transport Vesicle Membrane Protein Modification Process Transport Vesicle Vesicle Coating Protein Ubiquitination Golgi Organization Maintenance Of Protein Localization In Organelle Cis-Golgi Network Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Maintenance Of Protein Location In Cell Maintenance Of Protein Location Intracellular Protein Transport Maintenance Of Location In Cell COPI-coated Vesicle Post-translational Protein Modification Protein Tag Activity Maintenance Of Location COPII Vesicle Coat COPI-coated Vesicle Membrane Vesicle-mediated Transport Zymogen Granule Membrane Trans-Golgi Network Transport Vesicle COPII-coated Vesicle Cargo Loading Golgi Membrane In Utero Embryonic Development Chordate Embryonic Development COPII Vesicle Coating Golgi Apparatus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Viral Protein Processing Endoplasmic Reticulum Exit Site Positive Regulation Of Viral Genome Replication Protein Transport Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Metabolic Process	Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity
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