SEC23B and TMED2

Number of citations of the paper that reports this interaction (PubMedID 9472029)
69

Data Source:
BioGRID (unspecified method)

		SEC23B	TMED2
Description		SEC23 homolog B, COPII component	transmembrane p24 trafficking protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Zymogen Granule Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Frizzled Binding Smoothened Binding Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding	In Utero Embryonic Development Somitogenesis Neural Tube Closure Embryonic Placenta Development Maternal Placenta Development Heart Looping Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Inflammatory Response Endoplasmic Reticulum Organization Golgi Organization Intracellular Protein Localization Protein Secretion Positive Regulation Of Gene Expression Protein Transport Vesicle-mediated Transport Somite Rostral/caudal Axis Specification Negative Regulation Of GTPase Activity Multicellular Organism Growth Vesicle Cargo Loading Post-anal Tail Morphogenesis PERK-mediated Unfolded Protein Response Negative Regulation Of Smoothened Signaling Pathway COPI Coating Of Golgi Vesicle COPII Vesicle Coating Embryonic Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development Chorion Development Maintenance Of Protein Localization In Organelle Protein Localization To Plasma Membrane Endoplasmic Reticulum Membrane Organization Negative Regulation Of Protein Localization To Plasma Membrane Allantois Development Regulation Of SREBP Signaling Pathway
Pathways			Pre-NOTCH Processing in Golgi COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Refractive error ( 32231278)	Educational attainment ( 25201988) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 RIN1 SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UBA52 UBC UGT1A1	9 interacting genes: AKT2 ARF1 ARFGAP1 COPA GOLGA2 GORASP1 GORASP2 SEC23B TMED10
Entrez ID		10483	10959
HPRD ID		11543	17984
Ensembl ID		ENSG00000101310	ENSG00000086598
Uniprot IDs		A0A2R8YFH5 Q15437	Q15363 Q6FHT8
PDB IDs			5AZW
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Vesicle Cargo Loading Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Vesicle Transport COPII-coated ER To Golgi Transport Vesicle ER To Golgi Transport Vesicle Membrane Protein Modification Process Transport Vesicle Vesicle Coating Protein Ubiquitination Golgi Organization Maintenance Of Protein Localization In Organelle Cis-Golgi Network Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Maintenance Of Protein Location In Cell Maintenance Of Protein Location Intracellular Protein Transport Maintenance Of Location In Cell COPI-coated Vesicle Post-translational Protein Modification Protein Tag Activity Maintenance Of Location COPII Vesicle Coat COPI-coated Vesicle Membrane Vesicle-mediated Transport Zymogen Granule Membrane Trans-Golgi Network Transport Vesicle COPII-coated Vesicle Cargo Loading Golgi Membrane In Utero Embryonic Development Chordate Embryonic Development COPII Vesicle Coating Golgi Apparatus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Viral Protein Processing Endoplasmic Reticulum Exit Site Positive Regulation Of Viral Genome Replication Protein Transport Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Metabolic Process	Establishment Of Protein Localization Golgi Membrane Cis-Golgi Network Cellular Localization Intracellular Protein Localization Protein Transport Golgi Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle-mediated Transport Golgi Vesicle Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Ribbon Formation COPI-coated Vesicle Intracellular Protein Transport Vesicle Cargo Loading Vesicle Budding From Membrane Intracellular Transport COPII-coated ER To Golgi Transport Vesicle Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Syntaxin Binding Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Cellular Response To High Light Intensity Establishment Of Localization In Cell Mitotic Cleavage Furrow Ingression Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Response To High Light Intensity Retinal Rod Cell Apoptotic Process Cleavage Furrow Ingression Transport Vesicle Endoplasmic Reticulum Membrane Positive Regulation Of Cap-dependent Translational Initiation Localization Within Membrane Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Localization To Cell Leading Edge Positive Regulation Of Protein Glycosylation Vesicle Targeting, To, From Or Within Golgi Pancreatic Juice Secretion COPII-coated Vesicle Budding Positive Regulation Of Cytoplasmic Translational Initiation Golgi Disassembly COPI Coating Of Golgi Vesicle Retinal Cell Apoptotic Process Regulation Of Protein Glycosylation Gamma-secretase Complex Membrane
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