SEC23B and CPSF7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SEC23B	CPSF7
Description		SEC23 homolog B, COPII component	cleavage and polyadenylation specific factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding	MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways			mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Refractive error ( 32231278)
Interacting Genes		26 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 RIN1 SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UBA52 UBC UGT1A1	106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3
Entrez ID		10483	79869
HPRD ID		11543	16906
Ensembl ID		ENSG00000101310	ENSG00000149532
Uniprot IDs		A0A2R8YFH5 Q15437	B4DGF8 Q8N684
PDB IDs			3N9U
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Vesicle Cargo Loading Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Vesicle Transport COPII-coated ER To Golgi Transport Vesicle ER To Golgi Transport Vesicle Membrane Protein Modification Process Transport Vesicle Vesicle Coating Protein Ubiquitination Golgi Organization Maintenance Of Protein Localization In Organelle Cis-Golgi Network Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Maintenance Of Protein Location In Cell Maintenance Of Protein Location Intracellular Protein Transport Maintenance Of Location In Cell COPI-coated Vesicle Post-translational Protein Modification Protein Tag Activity Maintenance Of Location COPII Vesicle Coat COPI-coated Vesicle Membrane Vesicle-mediated Transport Zymogen Granule Membrane Trans-Golgi Network Transport Vesicle COPII-coated Vesicle Cargo Loading Golgi Membrane In Utero Embryonic Development Chordate Embryonic Development COPII Vesicle Coating Golgi Apparatus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Viral Protein Processing Endoplasmic Reticulum Exit Site Positive Regulation Of Viral Genome Replication Protein Transport Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization
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