MAOA

Gene Name		monoamine oxidase A
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Primary Amine Oxidase Activity
	Biological Process	Cellular Biogenic Amine Metabolic Process Xenobiotic Metabolic Process Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Dopamine clearance from the synaptic cleft Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Neurotransmitter Release Cycle Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Serotonin clearance from the synaptic cleft Amine Oxidase reactions Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Metabolism of serotonin Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Enzymatic degradation of Dopamine by monoamine oxidase Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Neurotransmitter Clearance In The Synaptic Cleft Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Transmission across Chemical Synapses
Drugs		Phentermine Tranylcypromine Phenelzine Minaprine Zonisamide Selegiline Moclobemide Isocarboxazid Ephedra MMDA 4-Methoxyamphetamine Methamphetamine Pargyline Flavin-Adenine Dinucleotide N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine Nialamide Nomifensine Zimelidine DECYL(DIMETHYL)PHOSPHINE OXIDE 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
Diseases
GWAS		Smoking behavior ( 19247474)
Protein-protein Interactions		1 interactors: NDRG1
Entrez ID		4128
HPRD ID		02400
Ensembl ID
Uniprot IDs		P21397 Q49A63 Q53YE7
PDB IDs		1H8Q 2BXR 2BXS 2Z5X 2Z5Y
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Spindle Checkpoint Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Regulation Of Spindle Checkpoint Myelin Maintenance Mast Cell Activation Regulation Of Cell Cycle Checkpoint Myelination In Peripheral Nervous System Schwann Cell Development Schwann Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Glial Cell Development Peripheral Nervous System Development Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Myelination Axon Ensheathment Glial Cell Differentiation Plasma Membrane Organization Positive Regulation Of Cell Cycle Process Gliogenesis Positive Regulation Of Cell Cycle Response To Hypoxia Response To Metal Ion Endomembrane System Organization Response To Inorganic Substance Leukocyte Activation Regulation Of Cell Cycle Process
Tagcloud ?		augments becomes ccne1 cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology