CALCOCO2 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 32296703)
51

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (two hybrid)

		CALCOCO2	GABARAPL2
Description		calcium binding and coiled-coil domain 2	GABA type A receptor associated protein like 2
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		10241	11345
HPRD ID		06846	16246
Ensembl ID		ENSG00000136436	ENSG00000034713
Uniprot IDs		Q13137	P60520
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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