GABARAPL2 and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		GABARAPL2	CLN8
Gene Name		GABA(A) receptor-associated protein-like 2	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Cytoplasm Autophagic Vacuole Golgi Apparatus Cytosol Extrinsic Component Of Membrane Cytoplasmic Vesicle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	SNARE Binding Protein Binding Microtubule Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATPase Activity Nucleophagy Membrane Fusion Negative Regulation Of Proteasomal Protein Catabolic Process	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		50 interactors: AAMP AGTRAP AHNAK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 CALCOCO1 CALCOCO2 CCDC155 CLN8 EGFR FUNDC1 GIMAP6 GOSR1 KBTBD7 KIAA1958 KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 MAP1LC3B MLX NBR1 NSF PTPRA RAP1A RAP2A RCN2 RPS2 SGTA SIK2 SQSTM1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TNIP1 TP53INP2 TSR2 UBA5 ULK1 ULK2 VDR YWHAZ	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		11345	2055
HPRD ID		16246	06383
Ensembl ID		ENSG00000034713	ENSG00000182372
Uniprot IDs		P60520	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Autophagy Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Cellular Response To Starvation Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Vacuole Organization Mitochondrion Degradation Organelle Disassembly Nucleophagy Membrane Organization Positive Regulation Of Autophagy Response To Stress Cellular Response To Nitrogen Starvation Catabolic Process Regulation Of Autophagy Response To External Stimulus Protein Localization Establishment Of Protein Localization Protein Delipidation Mitochondrion Organization Cellular Response To Stress Positive Regulation Of Metabolic Process Organelle Assembly C-terminal Protein Lipidation Establishment Of Protein Localization To Membrane Protein Localization To Membrane Protein Transport Positive Regulation Of Cellular Metabolic Process Intracellular Transport Cellular Localization Cell Communication Positive Regulation Of Macroautophagy Cellular Component Assembly Response To Stimulus Establishment Of Localization In Cell Cellular Response To Stimulus Protein Targeting To Membrane Regulation Of Signaling Regulation Of Signal Transduction Organelle Organization Cellular Metabolic Process Protein Lipidation Lipoprotein Biosynthetic Process Negative Regulation Of Collateral Sprouting Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?			brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?			brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?