GABARAPL2 and RETREG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GABARAPL2	RETREG1
Description		GABA type A receptor associated protein like 2	reticulophagy regulator 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle	Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cis-Golgi Network Membrane Nuclear Body
	Molecular Function	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity
	Biological Process	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Mitophagy Autophagy Endoplasmic Reticulum Organization Sensory Perception Of Pain Collagen Catabolic Process Negative Regulation Of Neuron Apoptotic Process White Fat Cell Differentiation Reticulophagy Substrate Localization To Autophagosome
Pathways		Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Diffusing capacity of carbon monoxide ( 30694715) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227)
Interacting Genes		103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	7 interacting genes: AMFR APP BDKRB1 GABARAPL2 MAP1LC3B MORC3 SNAPIN
Entrez ID		11345	54463
HPRD ID		16246	07879
Ensembl ID		ENSG00000034713	ENSG00000154153
Uniprot IDs		P60520	A0A804HHX5 Q9H6L5
PDB IDs		4CO7 6H8C 7LK3 7YO8 8Q6Q	7BRQ 7FB5
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding	Autophagosome Maturation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Protein-containing Complex Disassembly Vacuole Organization Response To Stress Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytoplasmic Vesicle Mitophagy Autophagosome Membrane Autophagy Of Mitochondrion SNARE Binding Positive Regulation Of Late Endosome To Lysosome Transport Axo-dendritic Transport Autophagosome Protein-folding Chaperone Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Bradykinin Receptor Activity Autophagosome Organization Autophagosome Assembly Golgi Apparatus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Phospholipid Binding Negative Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Organization Growth Cone BAT3 Complex Binding Regulation Of Calcium Ion Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Leukocyte Migration Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Endoplasmic Reticulum Negative Regulation Of Wnt Signaling Pathway
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