GABARAPL2 and PDLIM1

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GABARAPL2	PDLIM1
Description		GABA type A receptor associated protein like 2	PDZ and LIM domain 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion
Pathways		Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)
Interacting Genes		103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM
Entrez ID		11345	9124
HPRD ID		16246	09326
Ensembl ID		ENSG00000034713	ENSG00000107438
Uniprot IDs		P60520	O00151 V9HW92
PDB IDs		4CO7 6H8C 7LK3 7YO8 8Q6Q	1X62 2PKT
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding	Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton
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