GABARAPL2 and BNIP3L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GABARAPL2	BNIP3L
Description		GABA type A receptor associated protein like 2	BCL2 interacting protein 3 like
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Nuclear Speck
	Molecular Function	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Protein Binding Lamin Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macroautophagy Mitochondrial Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Defense Response To Virus Cellular Response To Hypoxia Mitochondrial Outer Membrane Permeabilization Regulation Of Mitophagy Regulation Of Protein Targeting To Mitochondrion
Pathways		Macroautophagy TBC/RABGAPs	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Schizophrenia ( 28991256 30285260)
Interacting Genes		103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	36 interacting genes: ADIPOQ BCL2 BCL2L1 BNIP3 CAMK1D CASK CLEC7A CLN8 CYB5B DOK5 DUSP3 ECM1 EWSR1 FATE1 FBXL4 GABARAPL1 GABARAPL2 GBP2 GNB5 HTR2B KLHL23 LDLRAD1 LMNA MALL MAP1LC3A NGFR RHEB RINT1 ROBO2 SMCO4 STEAP3 TMEM11 TMEM120B TMEM132D TMPRSS4 TNMD
Entrez ID		11345	665
HPRD ID		16246	07288
Ensembl ID		ENSG00000034713	ENSG00000104765
Uniprot IDs		P60520	O60238 Q6IBV1
PDB IDs		4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding	Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Membrane Neuron Apoptotic Process Mitochondrial Membrane Organization Phosphatidylethanolamine Binding Mitochondrial Outer Membrane Dendritic Cell Apoptotic Process Macroautophagy Ubiquitin Protein Ligase Binding Autophagy Vacuole Organization Autophagosome Assembly Response To Nutrient Levels BH3 Domain Binding Autophagosome Organization Negative Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxidative Stress Protein Binding Regulation Of Autophagy Positive Regulation Of Cell Maturation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Respiratory Burst Autophagosome Maturation Mitochondrion Organization Cellular Response To Nutrient Levels Identical Protein Binding Autophagosome Membrane Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Regulation Of Mitochondrial Membrane Permeability Response To Oxygen-glucose Deprivation Regulation Of Endothelial Cell Proliferation Nuclear Lamina Regulation Of Locomotion Cellular Response To Oxygen Levels Negative Regulation Of Apoptotic Process Chemical Homeostasis Response To Stress Apoptotic Mitochondrial Changes Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Apoptotic Process Response To Decreased Oxygen Levels Negative Regulation Of Programmed Cell Death GABA Receptor Binding
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