CALCOCO2 and MYO6

Number of citations of the paper that reports this interaction (PubMedID 31371777)
63

Data Source:
BioGRID (two hybrid, pull down, fluorescent resonance energy transfer, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology)

		CALCOCO2	MYO6
Description		calcium binding and coiled-coil domain 2	myosin VI
Image
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion
Pathways			Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases			Deafness, autosomal recessive Deafness, autosomal dominant
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80	24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2
Entrez ID		10241	4646
HPRD ID		06846	02985
Ensembl ID		ENSG00000136436	ENSG00000196586
Uniprot IDs		Q13137	A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA	2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule	Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?