CALCOCO2 and ATG5

Number of citations of the paper that reports this interaction (PubMedID 27879200)
69

Data Source:
BioGRID (pull down)

		CALCOCO2	ATG5
Description		calcium binding and coiled-coil domain 2	autophagy related 5
Image
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Autophagosome Cytosol Axoneme Membrane Axon Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Synapse Phagophore Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Transferase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding Atg8-family Ligase Activity
	Biological Process	Autophagy Viral Process Response To Type II Interferon Xenophagy Positive Regulation Of Autophagosome Maturation	Autophagosome Assembly Mitophagy Blood Vessel Remodeling Immune System Process Regulation Of Cytokine Production Involved In Immune Response Chromatin Organization Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Cellular Response To Starvation Response To Xenobiotic Stimulus Response To Fungus Response To Iron(II) Ion Positive Regulation Of Autophagy Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Macroautophagy Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Post-translational Protein Modification Negative Thymic T Cell Selection Innate Immune Response Negative Regulation Of Innate Immune Response Otolith Development Negative Regulation Of Defense Response To Virus Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Establishment Of Localization In Cell Ventricular Cardiac Muscle Cell Development Heart Contraction Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Mucus Secretion Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Axonal Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Autophagosome Maturation Regulation Of Cilium Assembly Response To Fluoride Negative Regulation Of Autophagic Cell Death Positive Regulation Of Viral Translation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 33875642 27363682) Rheumatoid arthritis ( 24390342 30423114) Systemic lupus erythematosus ( 28714469 19838193 27399966 26502338 23273568) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 24387989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		182 interacting genes: ABLIM1 ADSL AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 ATOSB AXIN1 BAHD1 BCL6B CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 ENTREP1 EXOSC5 FAM107A FAM161A FAM168A FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FUBP3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPA1 HNRNPK HNRNPLL HOXB5 HOXB9 IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBRG4 TCL1A TEKT3 TENT2 TLE5 TNFAIP3 TP53RK TRAF2 TRAF4 TSC1 TSGA10IP TTC23L UBAC2 UBC ULK1 USP2 VARS1 VPS72 WWP2 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80	31 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 MYC NLRP6 OPTN PSMB11 RACK1 TECPR1 TEKT4 TIAM1 TRIM21 USP13 VCP WDFY3
Entrez ID		10241	9474
HPRD ID		06846	16051
Ensembl ID		ENSG00000136436	ENSG00000057663
Uniprot IDs		Q13137	A0A2R8Y718 A9UGY9 Q7Z3H3 Q9H1Y0
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA	4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW 7W36
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding MRNA Processing MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Cytoplasm RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process RNA Metabolic Process Metal Ion Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nutrient Levels RNA Processing Macromolecule Metabolic Process Response To Starvation Autophagy Of Mitochondrion Spliceosomal Complex Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of MRNA Metabolic Process Autophagosome Autophagosome Membrane Negative Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission SnRNP Binding Mitophagy Negative Regulation Of Nucleobase-containing Compound Metabolic Process Phosphatidylethanolamine Binding Negative Regulation Of Gene Expression Cytoplasmic Stress Granule	Autophagy Macroautophagy Regulation Of Autophagy Autophagosome Atg12-Atg5-Atg16 Complex Catabolic Process Autophagosome Membrane Regulation Of Autophagosome Maturation Autophagosome Assembly Cytosol Vacuole Organization Positive Regulation Of Catabolic Process Autophagosome Organization Cytoplasm Protein-containing Complex Disassembly Identical Protein Binding Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Autophagosome Maturation C-terminal Protein Lipidation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Genome Replication Phagophore Assembly Site Membrane Macromolecule Catabolic Process Negative Stranded Viral RNA Replication Signaling Adaptor Activity Protein Transport Positive Regulation Of Autophagy Calpain Complex BAT3 Complex Binding Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Protein-containing Complex Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune System Process BH3 Domain Binding Regulation Of Proteolysis Establishment Of Protein Localization Response To Virus Stress Granule Disassembly Xenophagy Positive Regulation Of Autophagosome Maturation Viral RNA Genome Replication Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Xenophagy Post-translational Protein Modification Protein Catabolic Process Positive Regulation Of Cellular Component Organization Protein-containing Complex Organization
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