GABARAPL2 and BICC1

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		GABARAPL2	BICC1
Description		GABA type A receptor associated protein like 2	BicC family RNA binding protein 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle	Cytoplasm
	Molecular Function	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	Nucleic Acid Binding RNA Binding
	Biological Process	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Kidney Development Determination Of Left/right Symmetry Heart Development Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Blood urea nitrogen levels ( 31152163 29403010) Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Intraocular pressure ( 31959993) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Manganese levels ( 26025379) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Midgestational circulating levels of PCBs ( 28235828) Morning person ( 30696823) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278 23396134) Serum uric acid levels ( 30993211 29403010) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Urate levels ( 31985003 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774	4 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3C
Entrez ID		11345	80114
HPRD ID		16246	18993
Ensembl ID		ENSG00000034713	ENSG00000122870
Uniprot IDs		P60520	Q9H694
PDB IDs		4CO7 6H8C 7LK3 7YO8 8Q6Q	4RQM 4RQN 6GY4
Enriched GO Terms of Interacting Partners?		Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly GABA Receptor Binding Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Beta-tubulin Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Ubiquitin Protein Ligase Binding Response To Nutrient Levels Organelle Assembly Cytoplasmic Vesicle Microtubule Protein-containing Complex Organization L-cysteine Transaminase Activity Cellular Response To Stress Positive Regulation Of Protein K48-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Microtubule Binding Endomembrane System Tat Protein Binding Protein Transport Glycophagy Cellular Component Assembly Aggrephagy Organelle Organization Protein Localization To Endoplasmic Reticulum Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Polyubiquitination Establishment Of Protein Localization Regulation Of Protein Catabolic Process Smooth Endoplasmic Reticulum Regulation Of Proteolysis Positive Regulation Of ATP-dependent Activity Glycogen Catabolic Process Golgi Apparatus Polysaccharide Catabolic Process
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