RASGRP2 and RAP1A

Number of citations of the paper that reports this interaction (PMID 14702343)
19

Data Source:
HPRD (in vivo, in vitro)

		RASGRP2	RAP1A
Gene Name		RAS guanyl releasing protein 2 (calcium and DAG-regulated)	RAP1A, member of RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Ruffle Membrane Neuron Projection Synapse	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding Diacylglycerol Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Ras Protein Signal Transduction Blood Coagulation Platelet Activation Positive Regulation Of Rap GTPase Activity Cellular Response To Calcium Ion	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		G alpha (q) signalling events Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System	Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS		Urate levels ( 21768215)	Osteoporosis ( 20548944)
Protein-Protein Interactions		6 interactors: APP FAM118B KRAS NRAS PTCHD2 RAP1A	41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C
Entrez ID		10235	5906
HPRD ID		09278	01545
Ensembl ID		ENSG00000068831	ENSG00000116473
Uniprot IDs		A6NDC7 Q7LDG7	A8KAH9 P62834
PDB IDs		2MA2	1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Visual Learning Visual Behavior Activation Of MAPKK Activity Positive Regulation Of Rac Protein Signal Transduction Associative Learning Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Learning Wound Healing Response To Wounding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Learning Or Memory Activation Of Protein Kinase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Protein Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphorylation Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Small GTPase Mediated Signal Transduction Single-organism Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Lung Morphogenesis Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Generation Of Neurons Regulation Of Cell Differentiation Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus	Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation
Tagcloud ?			bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?			bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?