RASGRP2

Gene Name		RAS guanyl releasing protein 2 (calcium and DAG-regulated)
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Ruffle Membrane Neuron Projection Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding Diacylglycerol Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Ras Protein Signal Transduction Blood Coagulation Platelet Activation Positive Regulation Of Rap GTPase Activity Cellular Response To Calcium Ion
Pathways		G alpha (q) signalling events Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-protein Interactions		6 interactors: APP FAM118B KRAS NRAS PTCHD2 RAP1A
Entrez ID		10235
HPRD ID		09278
Ensembl ID		ENSG00000068831
Uniprot IDs		A6NDC7 Q7LDG7
PDB IDs		2MA2
Enriched GO Terms of Interacting Partners?		Visual Learning Visual Behavior Activation Of MAPKK Activity Positive Regulation Of Rac Protein Signal Transduction Associative Learning Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Learning Wound Healing Response To Wounding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Learning Or Memory Activation Of Protein Kinase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Protein Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphorylation Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Small GTPase Mediated Signal Transduction Single-organism Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Lung Morphogenesis Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Generation Of Neurons Regulation Of Cell Differentiation Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus
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