RASGRP2 and NRAS

Number of citations of the paper that reports this interaction (PMID 10918068)
29

Data Source:
HPRD (in vitro, in vivo)

		RASGRP2	NRAS
Gene Name		RAS guanyl releasing protein 2 (calcium and DAG-regulated)	neuroblastoma RAS viral (v-ras) oncogene homolog
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Ruffle Membrane Neuron Projection Synapse	Golgi Membrane Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding Diacylglycerol Binding	GTP Binding Protein Complex Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Ras Protein Signal Transduction Blood Coagulation Platelet Activation Positive Regulation Of Rap GTPase Activity Cellular Response To Calcium Ion	MAPK Cascade Activation Of MAPKK Activity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Skeletal Muscle Tissue Development Leukocyte Migration Striated Muscle Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		G alpha (q) signalling events Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		6 interactors: APP FAM118B KRAS NRAS PTCHD2 RAP1A	19 interactors: ACVR1 ARHGAP4 BCL2 DNAJB1 EEF1A1 PIK3CA PIK3CG PLCE1 RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RPS20 SHOC2 SMAD4 SMURF2 SRI
Entrez ID		10235	4893
HPRD ID		09278	01273
Ensembl ID		ENSG00000068831	ENSG00000213281
Uniprot IDs		A6NDC7 Q7LDG7	P01111 Q5U091
PDB IDs		2MA2	3CON
Enriched GO Terms of Interacting Partners?		Visual Learning Visual Behavior Activation Of MAPKK Activity Positive Regulation Of Rac Protein Signal Transduction Associative Learning Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Learning Wound Healing Response To Wounding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Learning Or Memory Activation Of Protein Kinase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Protein Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphorylation Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Small GTPase Mediated Signal Transduction Single-organism Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Lung Morphogenesis Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Generation Of Neurons Regulation Of Cell Differentiation Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus	Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Ras Protein Signal Transduction Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cardiovascular System Development Cellular Response To Organic Substance Regulation Of Growth Regulation Of Cell Growth Response To Organic Substance Endocardial Cell Differentiation Positive Regulation Of Hydrolase Activity Cell Activation Regulation Of Protein Phosphorylation Response To Wounding Cell Proliferation Cellular Metal Ion Homeostasis Positive Regulation Of GTPase Activity Platelet Activation Blood Coagulation Hemostasis Cellular Cation Homeostasis Regulation Of GTPase Activity Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation BMP Signaling Pathway Stem Cell Development
Tagcloud ?			12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?			12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Intersection) ?