RASGRP2 and PTCHD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RASGRP2	PTCHD2
Gene Name		RAS guanyl releasing protein 2 (calcium and DAG-regulated)	patched domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Ruffle Membrane Neuron Projection Synapse	Endoplasmic Reticulum Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding Diacylglycerol Binding	Molecular_function Hedgehog Receptor Activity
	Biological Process	Regulation Of Cell Growth Signal Transduction Ras Protein Signal Transduction Blood Coagulation Platelet Activation Positive Regulation Of Rap GTPase Activity Cellular Response To Calcium Ion	Smoothened Signaling Pathway Regulation Of Lipid Transport Cholesterol Homeostasis
Pathways		G alpha (q) signalling events Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		6 interactors: APP FAM118B KRAS NRAS PTCHD2 RAP1A	4 interactors: CA2 CEACAM5 MYCBP RASGRP2
Entrez ID		10235	57540
HPRD ID		09278	13852
Ensembl ID		ENSG00000068831	ENSG00000204624
Uniprot IDs		A6NDC7 Q7LDG7	Q9P2K9
PDB IDs		2MA2
Enriched GO Terms of Interacting Partners?		Visual Learning Visual Behavior Activation Of MAPKK Activity Positive Regulation Of Rac Protein Signal Transduction Associative Learning Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Learning Wound Healing Response To Wounding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Learning Or Memory Activation Of Protein Kinase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Protein Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphorylation Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Small GTPase Mediated Signal Transduction Single-organism Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Lung Morphogenesis Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Generation Of Neurons Regulation Of Cell Differentiation Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus	Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Chloride Transport Positive Regulation Of Cellular PH Reduction Response To Metal Ion Angiotensin-activated Signaling Pathway Negative Regulation Of Myotube Differentiation Response To Inorganic Substance Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Anoikis Positive Regulation Of Bone Resorption Cellular Response To Fluid Shear Stress Positive Regulation Of Rap GTPase Activity Regulation Of Anoikis Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Tissue Remodeling Bicarbonate Transport Regulation Of Bone Resorption Regulation Of Synaptic Transmission, GABAergic Response To Fluid Shear Stress Response To PH Negative Regulation Of Muscle Cell Differentiation Regulation Of Bone Remodeling One-carbon Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Response To Zinc Ion Cellular Response To Calcium Ion Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Myotube Differentiation
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