RASGRP2 and DISP3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RASGRP2	DISP3
Description		RAS guanyl releasing protein 2	dispatched RND transporter family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Neuron Projection Synapse	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Cellular Response To Calcium Ion	Lipid Metabolic Process Smoothened Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Cell Differentiation Regulation Of Lipid Transport Cholesterol Homeostasis Negative Regulation Of Neuron Differentiation Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Effects of PIP2 hydrolysis FCERI mediated NF-kB activation Integrin signaling Rap1 signalling
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Interacting Genes		9 interacting genes: APP CEBPA DAPK1 DISP3 FAM118B KRAS NRAS RAP1A SNCA	5 interacting genes: CA2 CEACAM5 MTNR1B MYCBP RASGRP2
Entrez ID		10235	57540
HPRD ID		09278	13852
Ensembl ID		ENSG00000068831	ENSG00000204624
Uniprot IDs		B3KV60 Q7LDG7	Q9P2K9
PDB IDs		2MA2 6AXF
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity GDP Binding G Protein Activity Protein-containing Complex Binding Liver Development GTP Binding Intracellular Signaling Cassette Regulation Of Presynapse Organization Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Cellular Response To Metal Ion Cellular Response To Copper Ion Identical Protein Binding Amyloid Fibril Formation Positive Regulation Of Catabolic Process Regulation Of Synaptic Plasticity Response To Peptide Response To Cytokine Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Response To Copper Ion Cell Surface Receptor Signaling Pathway Negative Regulation Of Exocytosis Presynapse Cellular Response To Nerve Growth Factor Stimulus Homeostatic Process Response To Nerve Growth Factor Regulation Of Neuron Apoptotic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Cognition Visual Behavior Regulation Of Response To Calcium Ion Learning Or Memory Macrophage Activation Response To Growth Factor Amylin Binding Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Visual Learning	Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Chloride Transport Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep GPI Anchor Binding Regulation Of Monoatomic Anion Transport Carbonate Dehydratase Activity Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Diacylglycerol Binding Carbon Dioxide Transport Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Cytosolic Calcium Ion Concentration Angiotensin-activated Signaling Pathway Negative Regulation Of Myotube Differentiation Negative Regulation Of Anoikis Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle One-carbon Compound Transport Regulation Of Anoikis GTPase Regulator Activity
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