RASGRP2 and FAM118B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RASGRP2	FAM118B
Gene Name		RAS guanyl releasing protein 2 (calcium and DAG-regulated)	family with sequence similarity 118, member B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell Junction Ruffle Membrane Neuron Projection Synapse	Cajal Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Lipid Binding Diacylglycerol Binding
	Biological Process	Regulation Of Cell Growth Signal Transduction Ras Protein Signal Transduction Blood Coagulation Platelet Activation Positive Regulation Of Rap GTPase Activity Cellular Response To Calcium Ion
Pathways		G alpha (q) signalling events Signaling by GPCR Integrin alphaIIb beta3 signaling Platelet Aggregation (Plug Formation) Effects of PIP2 hydrolysis G alpha (q) signalling events GPCR downstream signaling FCERI mediated NF-kB activation Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		6 interactors: APP FAM118B KRAS NRAS PTCHD2 RAP1A	26 interactors: BAG5 CEP70 CTSB FAM118A FAM20C GNB2 ING5 ITFG1 KIAA1377 MCM3AP MED31 NGEF QARS RASGRP2 RBM48 SDCBP SEMA5B SETDB1 SHC1 SPRED1 SUMO1 SUMO1P1 TMSB4X VIM ZNF235 ZNF746
Entrez ID		10235	79607
HPRD ID		09278	07952
Ensembl ID		ENSG00000068831	ENSG00000197798
Uniprot IDs		A6NDC7 Q7LDG7	J3KP39 Q9BPY3
PDB IDs		2MA2
Enriched GO Terms of Interacting Partners?		Visual Learning Visual Behavior Activation Of MAPKK Activity Positive Regulation Of Rac Protein Signal Transduction Associative Learning Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Learning Wound Healing Response To Wounding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Learning Or Memory Activation Of Protein Kinase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Protein Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphorylation Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of MAPK Cascade Response To Radiation Positive Regulation Of Small GTPase Mediated Signal Transduction Single-organism Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Lung Morphogenesis Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Generation Of Neurons Regulation Of Cell Differentiation Axonogenesis Neurogenesis Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus	Regulation Of Metabolic Process Developmental Process Anatomical Structure Development Regulation Of Signal Transduction Platelet Activation Regulation Of Signaling Glutaminyl-tRNA Aminoacylation Osteoclast Maturation Ras Protein Signal Transduction Organelle Organization Regulation Of Cellular Component Organization Multicellular Organismal Development Peptidyl-lysine Modification Prolyl-tRNA Aminoacylation Regulation Of Cellular Process Small GTPase Mediated Signal Transduction Actin Filament-based Process Negative Regulation Of Dendritic Spine Morphogenesis Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Extracellular Vesicular Exosome Assembly Glutamyl-tRNA Aminoacylation PML Body Organization Negative Regulation Of Protein Refolding Odontoblast Differentiation Regulation Of Intracellular Signal Transduction
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