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TOPORS and H2AFX
Number of citations of the paper that reports this interaction (PMID
22972498
)
0
Data Source:
BioGRID
(enzymatic study)
TOPORS
H2AFX
Gene Name
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
H2A histone family, member X
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Gamma-tubulin Complex
Nucleus
Centriole
Cytoplasmic Dynein Complex
PML Body
Nuclear Speck
Midbody
Photoreceptor Connecting Cilium
Ciliary Basal Body
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Antigen Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Transferase Activity
DNA Topoisomerase Binding
Ubiquitin Protein Ligase Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Retina Layer Formation
Protein Sumoylation
Protein Localization To Nucleus
Photoreceptor Cell Outer Segment Organization
Regulation Of Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Retinal Rod Cell Development
Retinal Cone Cell Development
Positive Regulation Of Ubiquitin-protein Transferase Activity
Maintenance Of Protein Location In Nucleus
Protein K48-linked Ubiquitination
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Immune response to smallpox vaccine (IL-6) (
22610502
)
Protein-Protein Interactions
24 interactors:
CASP8
H2AFX
HABP4
MTDH
NKX3-1
SATB1
SERBP1
SIN3A
SNIP1
SUMO1
SUMO2
TOP1
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2J1
UBE2L6
UBE2N
UBE2W
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
10210
3014
HPRD ID
11642
03465
Ensembl ID
ENSG00000197579
ENSG00000188486
Uniprot IDs
Q9NS56
P16104
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Polyubiquitination
Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Cellular Macromolecule Catabolic Process
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Positive Regulation Of Innate Immune Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Ubiquitin-dependent Protein Catabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Response To Oxygen Levels
Regulation Of DNA-templated Transcription In Response To Stress
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Proteolysis
Response To Organic Substance
Negative Regulation Of Gene Expression
Cellular Protein Modification Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Proteolysis
Regulation Of Metabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Response To Hypoxia
Positive Regulation Of Cellular Protein Catabolic Process
Catabolic Process
DNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Abiotic Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
bindingprotein
blockade
condition
deprivation
diphosphate
e3
eliminates
ern1
finction
finger
glioma
glutamine
matrin
nm23
nme
nme6
nucleoside
ofrybpi
oftumor
regulatedpa26
rybp
sesn1
tp53
tp53bp1
tp53bpi
tp53tg1
u87
zmat3
Tagcloud (Difference)
?
bindingprotein
blockade
condition
deprivation
diphosphate
e3
eliminates
ern1
finction
finger
glioma
glutamine
matrin
nm23
nme
nme6
nucleoside
ofrybpi
oftumor
regulatedpa26
rybp
sesn1
tp53
tp53bp1
tp53bpi
tp53tg1
u87
zmat3
Tagcloud (Intersection)
?