TOPORS

Gene Name		topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity DNA Topoisomerase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-protein Interactions		24 interactors: CASP8 H2AFX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W
Entrez ID		10210
HPRD ID		11642
Ensembl ID		ENSG00000197579
Uniprot IDs		Q9NS56
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Innate Immune Response Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Oxygen Levels Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Proteolysis Response To Organic Substance Negative Regulation Of Gene Expression Cellular Protein Modification Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Proteolysis Regulation Of Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Hypoxia Positive Regulation Of Cellular Protein Catabolic Process Catabolic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process
Tagcloud ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp sesn1 tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3