TOPORS and HABP4

Number of citations of the paper that reports this interaction (PubMedID 16455055)
0

Data Source:
HPRD (two hybrid)

		TOPORS	HABP4
Description		TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	hyaluronan binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Cajal Body Sarcoplasm Nuclear Body Nuclear Speck Sarcomere Nuclear Membrane Gemini Of Cajal Bodies
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding SUMO Binding Ribosome Binding Translation Elongation Factor Binding
	Biological Process	Protein Polyubiquitination DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	MRNA Processing Regulation Of Translation RNA Splicing PML Body Organization Positive Regulation Of RNA Splicing Positive Regulation Of Translational Initiation Cellular Response To Mechanical Stimulus Ribosome Hibernation
Pathways		SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins	Platelet degranulation
Drugs			Hyaluronic acid
Diseases		Retinitis pigmentosa (RP)
GWAS		Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		30 interacting genes: CASP8 CREBBP EPM2A HABP4 MTDH NKX3-1 PRMT1 RAD51 SATB1 SERBP1 SETX SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1	27 interacting genes: C1QBP CHD3 CRK CRYAA DAXX ENO2 FRA10AC1 HMGXB4 KAT5 OGT PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 RACK1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1
Entrez ID		10210	22927
HPRD ID		11642	13628
Ensembl ID		ENSG00000197579	ENSG00000130956
Uniprot IDs		Q9NS56	Q5JVS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Macromolecule Metabolic Process Nucleoplasm Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding DNA Metabolic Process Proteolysis Protein Ubiquitination Macromolecule Catabolic Process Regulation Of Macromolecule Metabolic Process DNA Repair Ubiquitin-protein Transferase Activity Protein Metabolic Process PML Body DNA Damage Response Regulation Of Metabolic Process Double-strand Break Repair Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Body PML Body Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling RNA Binding Cellular Response To Stress Protein K48-linked Ubiquitination Catabolic Process ATP Binding Nucleic Acid Metabolic Process Protein Tag Activity Protein Monoubiquitination DNA Recombination Negative Regulation Of Transcription By RNA Polymerase II Nuclear Body Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Cellular Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process	Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein Kinase C Signaling Positive Regulation Of Biosynthetic Process Nucleus Apoptotic Process Programmed Cell Death Cell Death Regulation Of Programmed Cell Death Intracellular Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Presynaptic Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translation Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MRNA Metabolic Process PML Body Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Histone H3T6 Kinase Activity Positive Regulation Of Protein Metabolic Process Cytoplasm
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