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TOPORS and NKX3-1
Number of citations of the paper that reports this interaction (PMID
18077445
)
14
Data Source:
BioGRID
(enzymatic study)
TOPORS
NKX3-1
Gene Name
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
NK3 homeobox 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Gamma-tubulin Complex
Nucleus
Centriole
Cytoplasmic Dynein Complex
PML Body
Nuclear Speck
Midbody
Photoreceptor Connecting Cilium
Ciliary Basal Body
Intracellular
Nucleus
Molecular Function
DNA Binding
Antigen Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Transferase Activity
DNA Topoisomerase Binding
Ubiquitin Protein Ligase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity
Core Promoter Binding
Sequence-specific DNA Binding Transcription Factor Activity
Androgen Receptor Activity
Protein Binding
Transcription Factor Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Estrogen Receptor Activity
Protein Kinase Activator Activity
Estrogen Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Self-association
Transcription Regulatory Region DNA Binding
MADS Box Domain Binding
Biological Process
Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Retina Layer Formation
Protein Sumoylation
Protein Localization To Nucleus
Photoreceptor Cell Outer Segment Organization
Regulation Of Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Retinal Rod Cell Development
Retinal Cone Cell Development
Positive Regulation Of Ubiquitin-protein Transferase Activity
Maintenance Of Protein Location In Nucleus
Protein K48-linked Ubiquitination
Metanephros Development
Somitogenesis
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Multicellular Organismal Development
Salivary Gland Development
Heart Development
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Male Gonad Development
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Death
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Androgen Receptor Signaling Pathway
Response To Testosterone
Cellular Response To Drug
Dorsal Aorta Development
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Steroid Hormone Mediated Signaling Pathway
Protein Kinase B Signaling
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Division
Pharyngeal System Development
Branching Involved In Prostate Gland Morphogenesis
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Hypoxia
Mitotic Cell Cycle Arrest
Negative Regulation Of Estrogen Receptor Binding
Positive Regulation Of Androgen Secretion
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Immune response to smallpox vaccine (IL-6) (
22610502
)
Protein-Protein Interactions
24 interactors:
CASP8
H2AFX
HABP4
MTDH
NKX3-1
SATB1
SERBP1
SIN3A
SNIP1
SUMO1
SUMO2
TOP1
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2J1
UBE2L6
UBE2N
UBE2W
32 interactors:
AEN
CCT7
CHPF
CKAP4
FEM1B
HIPK2
HMG20B
HNRNPA0
HSP90B1
LMCD1
MAN2B1
MNAT1
ND4
PEBP1
PTMS
RABL6
RARG
RPL37A
RPSA
SP1
SP2
SP3
SP4
SP5
SPDEF
SRF
STMN3
STRA13
TEX264
TOPORS
TPT1
WDR77
Entrez ID
10210
4824
HPRD ID
11642
03620
Ensembl ID
ENSG00000197579
ENSG00000167034
Uniprot IDs
Q9NS56
Q99801
PDB IDs
2L9R
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Polyubiquitination
Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Cellular Macromolecule Catabolic Process
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Positive Regulation Of Innate Immune Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Ubiquitin-dependent Protein Catabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Response To Oxygen Levels
Regulation Of DNA-templated Transcription In Response To Stress
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Proteolysis
Response To Organic Substance
Negative Regulation Of Gene Expression
Cellular Protein Modification Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Proteolysis
Regulation Of Metabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Response To Hypoxia
Positive Regulation Of Cellular Protein Catabolic Process
Catabolic Process
DNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Abiotic Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription, DNA-templated
Embryonic Eye Morphogenesis
Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Embryonic Camera-type Eye Development
Regulation Of Transcription From RNA Polymerase II Promoter
Eye Morphogenesis
Biosynthetic Process
Megakaryocyte Differentiation
Trophectodermal Cell Differentiation
Camera-type Eye Development
Eye Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Erythrocyte Differentiation
Erythrocyte Homeostasis
Blastocyst Formation
Embryonic Camera-type Eye Morphogenesis
Camera-type Eye Morphogenesis
Organ Morphogenesis
Myeloid Cell Homeostasis
Organ Development
Embryonic Organ Development
Glandular Epithelial Cell Differentiation
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Embryonic Organ Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Embryonic Process Involved In Female Pregnancy
Sensory Organ Development
Prostate Gland Development
Regulation Of RNA Metabolic Process
Enucleate Erythrocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Tissue Development
System Development
Homeostasis Of Number Of Cells
Tagcloud
?
bindingprotein
blockade
condition
deprivation
diphosphate
e3
eliminates
ern1
finction
finger
glioma
glutamine
matrin
nm23
nme
nme6
nucleoside
ofrybpi
oftumor
regulatedpa26
rybp
sesn1
tp53
tp53bp1
tp53bpi
tp53tg1
u87
zmat3
Tagcloud (Difference)
?
bindingprotein
blockade
condition
deprivation
diphosphate
e3
eliminates
ern1
finction
finger
glioma
glutamine
matrin
nm23
nme
nme6
nucleoside
ofrybpi
oftumor
regulatedpa26
rybp
sesn1
tp53
tp53bp1
tp53bpi
tp53tg1
u87
zmat3
Tagcloud (Intersection)
?