TOPORS and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 18077445)
0

Data Source:
BioGRID (enzymatic study)

		TOPORS	NKX3-1
Description		TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	NK3 homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Prostate Gland Development Regulation Of Protein Localization Response To Testosterone Response To Lipid Dorsal Aorta Development Regulation Of Cell Population Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins
Drugs
Diseases		Retinitis pigmentosa (RP)	Prostate cancer
GWAS		Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 26443449 32986714 34012061) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		30 interacting genes: CASP8 CREBBP EPM2A HABP4 MTDH NKX3-1 PRMT1 RAD51 SATB1 SERBP1 SETX SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1	38 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MRE11 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC67A1 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		10210	4824
HPRD ID		11642	03620
Ensembl ID		ENSG00000197579	ENSG00000167034
Uniprot IDs		Q9NS56	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Macromolecule Metabolic Process Nucleoplasm Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding DNA Metabolic Process Proteolysis Protein Ubiquitination Macromolecule Catabolic Process Regulation Of Macromolecule Metabolic Process DNA Repair Ubiquitin-protein Transferase Activity Protein Metabolic Process PML Body DNA Damage Response Regulation Of Metabolic Process Double-strand Break Repair Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Body PML Body Organization Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of TOR Signaling RNA Binding Cellular Response To Stress Protein K48-linked Ubiquitination Catabolic Process ATP Binding Nucleic Acid Metabolic Process Protein Tag Activity Protein Monoubiquitination DNA Recombination Negative Regulation Of Transcription By RNA Polymerase II Nuclear Body Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Cellular Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleus DNA Binding PML Body Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Trachea Cartilage Development Sequence-specific Double-stranded DNA Binding Embryonic Eye Morphogenesis Glandular Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Double-stranded DNA Binding Regulation Of Programmed Cell Death DNA Damage Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Eye Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sensory Organ Morphogenesis Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Morphogenesis Zinc Ion Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Trophectodermal Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Face Development Regulation Of Macromolecule Biosynthetic Process Prostate Gland Epithelium Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Cellular Response To Stress Replication Fork Positive Regulation Of Macromolecule Metabolic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Thyroid Gland Development
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